From: Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis
Patient no. | Age (mo) | Sex | Parasitaemia (Pf) &/or Organism cultured | Admitting coma score | Parasites in brain vessels | Brain vessel monocyte HO-1 | Lung mono & alveol M HO-1 | Liver Kupffer cell HO-1 |
---|---|---|---|---|---|---|---|---|
4 | 20 | M | 19% | 2 | 1+ | isolated, mod | strong, fewer | strong |
7 | 29 | F | 4+ | 0 | 1+ | absent | strong, fewer | strong |
22 | 18 | M | 2% | 0 | 1+ | absent | strong, common | strong |
23 | 30 | F | 29% | 0 | 1+ | absent | strong, common | strong |
31 | 39 | M | 49% | 1 | 1+ | absent | PMN-obscured | strong |
33 | 25 | M | <1% | 0 | 1+ | absent | pale | strong |
37 | 6 | M | 34% & P. mal. trace | 2 | 1+ | scattered, mod | strong, fewer | strong |
38 | 84 | F | 22% | 0 | 1+ | scattered, mod | strong, fewer | strong |
45 | 34 | M | 3% | 0 | 1+ | absent | PMN-obscured | moderate |
47 | 22 | F | 11% | 1 | 1+ | absent | pale | strong |
49 | 17 | M | 0% | 1 | 1+ | absent | negative | moderate |
CM(B), sequestered parasites only | ||||||||
1 | 27 | F | 31% | 0 | 2+ | rare, strong | mod, fewer | strong |
5 | 14 | M | 4% | 1 | 4+ | scattered, strong | strong, common | strong |
16 | 51 | F | 6% | 1 | 2+ | rare, strong | strong, fewer | strong |
21 | 25 | F | <1% | 2 | 4+ | scattered, strong | strong, common | strong |
25 | 44 | F | <1% | 2 | 4+ | scattered, strong | strong, common | strong |
39 | 18 | M | <1% | 2 | 4+ | scattered, strong | strong, fewer | strong |
42 | 37 | F | 20% | 0 | 4+ | absent | PMN-obscured | NA |
CM(C), sequestered parasites plus local intravascular inflammation | ||||||||
6 | 17 | F | 6% | 0 | 3+ | accumul, strong | strong, common | strong |
9 | 16 | M | <1% | 1 | 3+ | accumul, strong | strong, fewer | strong |
11 | 29 | F | 29% & H. influ. B | 1 | 2+ | accumul, strong | PMN-obscured | strong |
13 | 22 | M | 37% | 0–1 | 3+ | scattered, strong | strong, common | strong |
15 | 8 | F | 1% | 2 | 2+ | accumul, strong | strong, fewer | strong |
26 | 30 | M | 19% | 1 | 4+ | accumul, strong | strong, common | strong |
27 | 20 | M | 53% & Sal. typhi-m | 0 | 3+ | accumul, strong | strong, fewer | strong |
28 | 61 | F | 23% | 0 | 2+ | scattered, strong | NA | strong |
29 | 43 | M | 33% | 2 | 3+ | accumul, strong | strong, fewer | strong |
32 | 18 | F | 47% | 0 | 3+ | accumul, strong | strong, fewer | strong |
34 | 70 | M | 2% | 1 | 4+ | accumul, strong | strong, common | strong |
35 | 114 | M | <1% | 1 | 3+ | accumul, strong | strong, common | strong |
36 | 21 | F | 1% | 2 | 2+ | accumul, strong | strong, fewer | strong |
48 | 48 | M | <1% | 2 | 3+ | accumul, strong | mod, fewer | strong |
COMA (bacteria cultured, and clinically judged not cerebral malaria) | ||||||||
12 | 6 | M | Sal. enteritidis | 2 | negative | scattered, strong | strong | strong, autolys |
14 | 9 | F | E. coli | 0 | negative | absent | strong | strong |
18 | 7 | F | H. influenzae B | 1 | negative | absent | absent | strong |
20 | 96 | F | Tuberculosis | 0 | negative | regionally strong | regionally strong | strong |
24 | 48 | F | Strep. pneumoniae | 3 | negative | rare, mod | absent | mod, autolys |
MALAWIAN CONTROLS (without terminal coma) | ||||||||
41 | 29 | F | Sal. typhimurium | 5 | negative | absent | absent | absent |
43 | 53 | M | suspect malaria | 2, then 5 | negative | absent | absent | pale, v. occas |
* 50 | 144 | F | Strep. pneumoniae | 5 | negative | absent | pale | pale, occas |
AUSTRALIAN CONTROLS | ||||||||
n= 6 | Â | F/M | NA | NA | negative | negative | NA | NA |