|
Patient no.
|
Age (mo)
|
Sex
|
Parasitaemia (Pf) &/or Organism cultured
|
Admitting coma score
|
Coma duration Before/After admission (h)
|
Brain vessel iNOS (n)
|
Brain vessel MIF (n)
|
Parasites in brain vessels
|
Chest Wall vessel iNOS
|
Chest Wall vessel MIF
|
Chest Wall muscle iNOS
|
|---|
|
4
|
20
|
M
|
18.6%
|
2
|
missing/6
|
0-1+ (6)
|
0 (3)
|
1+
|
0-1+
|
4+
|
2+
|
|
7
|
29
|
F
|
4+
|
0
|
1/1
|
0-1+ (6)
|
0 (3)
|
1+
|
0-1+
|
3+
|
4+
|
|
31
|
39
|
M
|
49%
|
1
|
7/22
|
0-1+ (9)
|
0 (3)
|
1+
|
0-1+
|
3+
|
0-1+
|
|
33
|
25
|
M
|
0.26%
|
0
|
2/15
|
0-1+ (8)
|
0 (3)
|
1+
|
2+
|
2+
|
0-1+
|
|
37
|
6
|
M
|
34% ¶ mal. trace
|
2
|
missing/14
|
0-1+ (9)
|
0 (3)
|
1+
|
3+
|
3+
|
3+
|
|
47
|
22
|
F
|
11%
|
1
|
6/44
|
0-1+ (13)
|
0 (3)
|
1+
|
0-1+
|
3+
|
0-1+
|
|
49
|
17
|
M
|
0.09%
|
1
|
2/34
|
0-1+ (12)
|
0 (3)
|
1+
|
2+
|
3+
|
4+
|
|
22
|
18
|
M
|
1.75%
|
0
|
1/3
|
2+ (8)
|
0 (3)
|
1+
|
3+
|
ND
|
2+
|
|
38
|
84
|
F
|
22%
|
0
|
5/35
|
2+ (9)
|
0 (3)
|
1+
|
0-1+
|
2+
|
0-1+
|
|
45
|
34
|
M
|
2.5%
|
0
|
8/28
|
2+ (13)
|
0 (3)
|
1+
|
0-1+
|
3+
|
0-1+
|
|
23
|
30
|
F
|
29%
|
0
|
5/7
|
3+ (9)
|
0 (3)
|
1+
|
3+
|
3+
|
0-1+
|
|
CM(B), sequestered parasites only
|
|
5
|
14
|
M
|
3.5%
|
1
|
NA/18
|
0-1+ (3)
|
0 (3)
|
4+
|
4+
|
3+
|
4+
|
|
21
|
25
|
F
|
0.33%
|
2
|
2/12
|
0-1+ (3)
|
0 (3)
|
4+
|
4+
|
4+
|
4+
|
|
16
|
51
|
F
|
5.5%
|
1
|
22/6
|
0-1+ (3)
|
0 (3)
|
2+
|
2+
|
4+
|
2+
|
|
39
|
18
|
M
|
0.27%
|
2
|
6/18
|
0-1+ (9)
|
0 (3)
|
4+
|
2+
|
3+
|
2+
|
|
42
|
37
|
F
|
20%
|
0
|
missing
|
0-1+ (11)
|
0 (3)
|
4+
|
3+
|
4+
|
2+
|
|
25
|
44
|
F
|
0.02%
|
2
|
1/11
|
2+ (8)
|
0 (3)
|
4+
|
3+
|
3+
|
0-1+
|
|
1
|
27
|
F
|
31.1%
|
0
|
7/18
|
3+ (3)
|
0 (3)
|
2+
|
2+
|
ND
|
2+
|
|
CM(C), sequestered parasites plus local intravascular inflammation
|
|
13
|
22
|
M
|
36.52%
|
0-1
|
15/1
|
0-1+ (3)
|
0 (3)
|
3+
|
2+
|
2+
|
2+
|
|
27
|
20
|
M
|
53.4% & Sal. typhi-m
|
0
|
missing/3
|
2+ (3)
|
0 (3)
|
3+
|
4+
|
3+
|
0-1+
|
|
28
|
61
|
F
|
23.6%
|
0
|
12/0
|
2+ (9)
|
0 (3)
|
2+
|
0-1+
|
2+
|
0-1+
|
|
29
|
43
|
M
|
33%
|
2
|
18/11
|
3+ (9)
|
0 (3)
|
3+
|
0-1+
|
3+
|
0-1+
|
|
32
|
18
|
F
|
47%
|
0
|
24/3
|
3+ (9)
|
0 (3)
|
3+
|
0-1+
|
4+
|
0-1+
|
|
34
|
70
|
M
|
2.4%
|
1
|
36/3
|
3+ (9)
|
0 (3)
|
4+
|
3+
|
3+
|
2+
|
|
35
|
114
|
M
|
0.21%
|
1
|
12/15
|
3+ (9)
|
0 (3)
|
3+
|
2+
|
2+
|
2+
|
|
36
|
21
|
F
|
0.88%
|
2
|
3/10
|
3+ (8)
|
0 (3)
|
2+
|
3+
|
3+
|
3+
|
|
48
|
48
|
M
|
0.03%
|
2
|
4/22
|
3+ (13)
|
0 (3)
|
3+
|
2+
|
2+
|
3+
|
|
6
|
17
|
F
|
5.8%
|
0
|
19/1
|
4+ (9)
|
0 (3)
|
3+
|
4+
|
3+
|
4+
|
|
9
|
16
|
M
|
0.03%
|
1
|
11/23
|
4+ (3)
|
0 (3)
|
3+
|
3+
|
3+
|
4+
|
|
11
|
29
|
F
|
29.5% & H. influ. B
|
1
|
28/30
|
4+ (3)
|
0 (3)
|
2+
|
4+
|
4+
|
4+
|
|
15
|
8
|
F
|
0.94%
|
2
|
8/15
|
4+ (3)
|
0 (3)
|
2+
|
3+
|
2+
|
3+
|
|
26
|
30
|
M
|
19%
|
1
|
1/31
|
4+ (9)
|
0 (3)
|
4+
|
4+
|
4+
|
missing
|
|
COMA (clinically judged not cerebral malaria)
|
|
* 8
|
41
|
F
|
negative
|
3
|
3/9
|
3+ (3)
|
0 (3)
|
negative
|
0-1+
|
4+
|
0-1+
|
|
10
|
66
|
F
|
0.01%
|
0
|
5/4
|
0-1+ (3)
|
0 (3)
|
negative
|
2+
|
0-1+
|
2+
|
|
12
|
6
|
M
|
Sal. enteritidis
|
2
|
1/4
|
0-1+ (3)
|
0 (3)
|
negative
|
2+
|
4+
|
2+
|
|
14
|
9
|
F
|
E. coli
|
0
|
missing
|
0-1+ (3)
|
0 (3)
|
negative
|
4+
|
4+
|
4+
|
|
17
|
51
|
F
|
negative
|
0
|
2/9
|
0-1+ (3)
|
0 (3)
|
negative
|
0-1+
|
0-1+
|
0-1+
|
|
18
|
7
|
F
|
H. influenzae B
|
1
|
48/14
|
0-1+ (3)
|
0 (3)
|
negative
|
3+
|
3+
|
4+
|
|
20
|
96
|
F
|
Tuberculosis
|
0
|
missing
|
0-1+ (3)
|
0 (3)
|
negative
|
4+
|
2+
|
0-1+
|
|
24
|
48
|
F
|
Strep. pneumoniae
|
3
|
missing
|
0-1+ (3)
|
0 (3)
|
negative
|
2+
|
4+
|
2+
|
|
40
|
26
|
F
|
0.02%
|
1
|
24/63
|
2+ (9)
|
0 (3)
|
negative
|
0-1+
|
4+
|
2+
|
|
44
|
21
|
F
|
negligible
|
1
|
7/3
|
0-1+ (13)
|
0 (3)
|
negative
|
2+
|
2+
|
2+
|
|
MALAWIAN CONTROLS (without terminal coma)
|
|
41
|
29
|
F
|
Sal. typhimurium
|
5
|
NA/NA
|
0-1+ (13)
|
0 (3)
|
negative
|
0-1+
|
0-1+
|
0-1+
|
|
* 50
|
144
|
F
|
Strep. pneumoniae
|
5
|
NA/NA
|
0-1+ (13)
|
0 (3)
|
negative
|
0-1+
|
3+
|
0-1+
|
|
AUSTRALIAN CONTROLS
|
|
n = 5
| |
F/M
|
NA
|
NA
|
NA/NA
|
NA
|
NA
|
negative
|
0-1+
|
0-1+
|
0-1+
|
|
n = 7
| |
F/M
|
NA
|
5
|
NA/NA
|
0-1+ (3)
|
0 (3 ea)
|
negative
|
NA
|
NA
|
NA
|
- * Serologically positive for HIV (n) Number of brains areas examined ND = not done NA = not applicable
