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Table 1 CM(A), no apparent brain pathology

From: Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children

Patient no.

Age (mo)

Sex

Parasitaemia (Pf) &/or Organism cultured

Admitting coma score

Coma duration Before/After admission (h)

Brain vessel iNOS (n)

Brain vessel MIF (n)

Parasites in brain vessels

Chest Wall vessel iNOS

Chest Wall vessel MIF

Chest Wall muscle iNOS

4

20

M

18.6%

2

missing/6

0-1+ (6)

0 (3)

1+

0-1+

4+

2+

7

29

F

4+

0

1/1

0-1+ (6)

0 (3)

1+

0-1+

3+

4+

31

39

M

49%

1

7/22

0-1+ (9)

0 (3)

1+

0-1+

3+

0-1+

33

25

M

0.26%

0

2/15

0-1+ (8)

0 (3)

1+

2+

2+

0-1+

37

6

M

34% ¶ mal. trace

2

missing/14

0-1+ (9)

0 (3)

1+

3+

3+

3+

47

22

F

11%

1

6/44

0-1+ (13)

0 (3)

1+

0-1+

3+

0-1+

49

17

M

0.09%

1

2/34

0-1+ (12)

0 (3)

1+

2+

3+

4+

22

18

M

1.75%

0

1/3

2+ (8)

0 (3)

1+

3+

ND

2+

38

84

F

22%

0

5/35

2+ (9)

0 (3)

1+

0-1+

2+

0-1+

45

34

M

2.5%

0

8/28

2+ (13)

0 (3)

1+

0-1+

3+

0-1+

23

30

F

29%

0

5/7

3+ (9)

0 (3)

1+

3+

3+

0-1+

CM(B), sequestered parasites only

5

14

M

3.5%

1

NA/18

0-1+ (3)

0 (3)

4+

4+

3+

4+

21

25

F

0.33%

2

2/12

0-1+ (3)

0 (3)

4+

4+

4+

4+

16

51

F

5.5%

1

22/6

0-1+ (3)

0 (3)

2+

2+

4+

2+

39

18

M

0.27%

2

6/18

0-1+ (9)

0 (3)

4+

2+

3+

2+

42

37

F

20%

0

missing

0-1+ (11)

0 (3)

4+

3+

4+

2+

25

44

F

0.02%

2

1/11

2+ (8)

0 (3)

4+

3+

3+

0-1+

1

27

F

31.1%

0

7/18

3+ (3)

0 (3)

2+

2+

ND

2+

CM(C), sequestered parasites plus local intravascular inflammation

13

22

M

36.52%

0-1

15/1

0-1+ (3)

0 (3)

3+

2+

2+

2+

27

20

M

53.4% & Sal. typhi-m

0

missing/3

2+ (3)

0 (3)

3+

4+

3+

0-1+

28

61

F

23.6%

0

12/0

2+ (9)

0 (3)

2+

0-1+

2+

0-1+

29

43

M

33%

2

18/11

3+ (9)

0 (3)

3+

0-1+

3+

0-1+

32

18

F

47%

0

24/3

3+ (9)

0 (3)

3+

0-1+

4+

0-1+

34

70

M

2.4%

1

36/3

3+ (9)

0 (3)

4+

3+

3+

2+

35

114

M

0.21%

1

12/15

3+ (9)

0 (3)

3+

2+

2+

2+

36

21

F

0.88%

2

3/10

3+ (8)

0 (3)

2+

3+

3+

3+

48

48

M

0.03%

2

4/22

3+ (13)

0 (3)

3+

2+

2+

3+

6

17

F

5.8%

0

19/1

4+ (9)

0 (3)

3+

4+

3+

4+

9

16

M

0.03%

1

11/23

4+ (3)

0 (3)

3+

3+

3+

4+

11

29

F

29.5% & H. influ. B

1

28/30

4+ (3)

0 (3)

2+

4+

4+

4+

15

8

F

0.94%

2

8/15

4+ (3)

0 (3)

2+

3+

2+

3+

26

30

M

19%

1

1/31

4+ (9)

0 (3)

4+

4+

4+

missing

COMA (clinically judged not cerebral malaria)

* 8

41

F

negative

3

3/9

3+ (3)

0 (3)

negative

0-1+

4+

0-1+

10

66

F

0.01%

0

5/4

0-1+ (3)

0 (3)

negative

2+

0-1+

2+

12

6

M

Sal. enteritidis

2

1/4

0-1+ (3)

0 (3)

negative

2+

4+

2+

14

9

F

E. coli

0

missing

0-1+ (3)

0 (3)

negative

4+

4+

4+

17

51

F

negative

0

2/9

0-1+ (3)

0 (3)

negative

0-1+

0-1+

0-1+

18

7

F

H. influenzae B

1

48/14

0-1+ (3)

0 (3)

negative

3+

3+

4+

20

96

F

Tuberculosis

0

missing

0-1+ (3)

0 (3)

negative

4+

2+

0-1+

24

48

F

Strep. pneumoniae

3

missing

0-1+ (3)

0 (3)

negative

2+

4+

2+

40

26

F

0.02%

1

24/63

2+ (9)

0 (3)

negative

0-1+

4+

2+

44

21

F

negligible

1

7/3

0-1+ (13)

0 (3)

negative

2+

2+

2+

MALAWIAN CONTROLS (without terminal coma)

41

29

F

Sal. typhimurium

5

NA/NA

0-1+ (13)

0 (3)

negative

0-1+

0-1+

0-1+

* 50

144

F

Strep. pneumoniae

5

NA/NA

0-1+ (13)

0 (3)

negative

0-1+

3+

0-1+

AUSTRALIAN CONTROLS

n = 5

 

F/M

NA

NA

NA/NA

NA

NA

negative

0-1+

0-1+

0-1+

n = 7

 

F/M

NA

5

NA/NA

0-1+ (3)

0 (3 ea)

negative

NA

NA

NA

  1. * Serologically positive for HIV (n) Number of brains areas examined ND = not done NA = not applicable
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Malaria Journal

ISSN: 1475-2875

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