Table 1 Matched pair analysis of children with severe malaria and asymptomatic parasitaemic controls: risk of symptoms and conditions of severe malaria

absolute number (%)

All (n = 289)

F-segment

201 (70)

176 (61)

F-/C-segment

33 (11)

64 (22)

.5 [.3–.7] .003

C-segment

55 (19)

49 (17)

1.0 [.6–1.7] 1

Severe anaemia (n = 159)

F-segment

114 (72)

95 (60)

F-/C-segment

18 (11)

37 (23)

.4 [.2–.8] .02

C-segment

27 (17)

26 (16)

.9 [.4–1.8] .9

Prostration (n = 97)

F-segment

67 (69)

55 (57)

F-/C-segment

10 (10)

23 (24)

.4 [.1–1.0] .06

C-segment

20 (21)

18 (19)

.8 [.3–2.0]. .8

Respiratory Distress (n = 66)

F-segment

40 (61)

47 (71)

F-/C-segment

9 (14)

10 (15)

1.2 [.4–3.7] 1

C-segment

17 (26)

9 (14)

2.0 [.8–7.7] .2

Multiple Convulsions (n = 59)

F-segment

40 (68)

36 (61)

F-/C-segment

6 (10)

15 (25)

.4 [.1–1.1] .1

C-segment

13 (22)

8 (14)

2.0 [.6–6.3] .4

Impaired Consciousness (n = 56)

F-segment

36 (64)

39 (70)

F-/C-segment

8 (14)

9 (16)

1 [.3–3.6] 1

C-segment

12 (21)

8 (14)

1.6 [.5–4.6] .6

Jaundice (n = 34)

F-segment

23 (68)

21 (62)

F-/C-segment

3 (9)

6 (18)

.5 [.04–2.5] .7

C-segment

8 (24)

7 (21)

1 [.3–3.6] 1

Circulatory collapse (n = 10)

F-segment

6 (60)

8 (80)

F-/C-segment

0 (0)

1 (10)

-

C-segment

4 (40)

1 (10)

3.0 [.4–3.0] .6

Haemoglobinuria (n = 8)

F-segment

6 (75)

5 (63)

F-/C-segment

0 (0)

1 (13)

-

C-segment

2 (25)

2 (25)

.5 [0–4.9] 1

Hyperparasitaemia (n = 64)

F-segment

43 (67)

47 (73)

F-/C-segment

6 (9)

10 (16)

.4 [.1–1.6] .3

C-segment

15 (23)

7 (11)

3. 7 [1.1–13.1] .06

Fatal outcome (n = 32)

F-segment

15 (47)

18 (56)

F-/C-segment

4 (13)

7 (22)

.5 [.04–2.5] .7

C-segment

13 (41)

6 (19)

4.0 [.9–19.4] .1