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Table 1 Matched pair analysis of children with severe malaria and asymptomatic parasitaemic controls: risk of symptoms and conditions of severe malaria

From: Allelic dimorphism of the erythocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children

Condition/Symptom Dimorphism Severe malaria Parasitaemic controls OR [95% CI] P value (F-segment as reference)
   absolute number (%)  
All (n = 289) F-segment 201 (70) 176 (61)  
  F-/C-segment 33 (11) 64 (22) .5 [.3–.7] .003
  C-segment 55 (19) 49 (17) 1.0 [.6–1.7] 1
Severe anaemia (n = 159) F-segment 114 (72) 95 (60)  
  F-/C-segment 18 (11) 37 (23) .4 [.2–.8] .02
  C-segment 27 (17) 26 (16) .9 [.4–1.8] .9
Prostration (n = 97) F-segment 67 (69) 55 (57)  
  F-/C-segment 10 (10) 23 (24) .4 [.1–1.0] .06
  C-segment 20 (21) 18 (19) .8 [.3–2.0]. .8
Respiratory Distress (n = 66) F-segment 40 (61) 47 (71)  
  F-/C-segment 9 (14) 10 (15) 1.2 [.4–3.7] 1
  C-segment 17 (26) 9 (14) 2.0 [.8–7.7] .2
Multiple Convulsions (n = 59) F-segment 40 (68) 36 (61)  
  F-/C-segment 6 (10) 15 (25) .4 [.1–1.1] .1
  C-segment 13 (22) 8 (14) 2.0 [.6–6.3] .4
Impaired Consciousness (n = 56) F-segment 36 (64) 39 (70)  
  F-/C-segment 8 (14) 9 (16) 1 [.3–3.6] 1
  C-segment 12 (21) 8 (14) 1.6 [.5–4.6] .6
Jaundice (n = 34) F-segment 23 (68) 21 (62)  
  F-/C-segment 3 (9) 6 (18) .5 [.04–2.5] .7
  C-segment 8 (24) 7 (21) 1 [.3–3.6] 1
Circulatory collapse (n = 10) F-segment 6 (60) 8 (80)  
  F-/C-segment 0 (0) 1 (10) -
  C-segment 4 (40) 1 (10) 3.0 [.4–3.0] .6
Haemoglobinuria (n = 8) F-segment 6 (75) 5 (63)  
  F-/C-segment 0 (0) 1 (13) -
  C-segment 2 (25) 2 (25) .5 [0–4.9] 1
Hyperparasitaemia (n = 64) F-segment 43 (67) 47 (73)  
  F-/C-segment 6 (9) 10 (16) .4 [.1–1.6] .3
  C-segment 15 (23) 7 (11) 3. 7 [1.1–13.1] .06
Fatal outcome (n = 32) F-segment 15 (47) 18 (56)  
  F-/C-segment 4 (13) 7 (22) .5 [.04–2.5] .7
  C-segment 13 (41) 6 (19) 4.0 [.9–19.4] .1