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Table 1 Enzymes and proteins involved in redox metabolism and their gene/locus in the P. falciparum genome.

From: Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome

Process Enzyme/protein EC number Gene/locus
ROS generation Fe-superoxide dismutase (possibly an Mn enzyme) 1.15.1.1 PF08_0071
MAL6P1.194
Glutathione biosynthesis and reccycling Glutamate-cysteine ligase 6.3.2.2 PFI0925w
  Glutathione synthase 6.3.2.3 PFE0605c
  Gluathione reductase 1.8.1.7 PF14_0192
  Glutathione-S-transferase 2.5.1.18 PF14_0187
  MRP   PFA0590w
PFL1410c
Glutathione utilization Glutathione-S-transferase 2.5.1.18 PF14_0187
  1-Cys peroxiredoxin   PF08_0131
  Glutaredoxin   PFC0271c
  Glutaerdoxin-like protein   MAL6P1.72
  Glutaerdoxin-like protein   PFC0205c
  Lactoylglutathione lyase (glyoxalase I) 4.4.1.5 PF11_0145
  Hydoxyacylglutathione hydrolase (glyoxalase II) 3.1.2.6 chr4.gen_37
PFL0285w;
Thioredoxin synthesis and recycling Thioredoxin   MAL13P1.225
    PF14_0545
    PFI0790w
    PFI1250w
  Plasmoredoxin   PFC0165w
  Thioredoxin reductase 1.8.1.9 PFI1170c
Thioredoxin utilization Peroxiredoxin   MAL7P1.159
  Trx peroxidase (TPxP) is a   PF14_0368, 2-cys
  2-Cys peroxiredoxin   PFL0725w; 2-cys
  Glutathione peroxidase 1.11.1.9 PFL0595c
  Ribonucleotide reductase, small chain 1.17.4.1 PF10_0154
    PF14_0053
Oxidative protein folding Protein-disulfde isomerase 5.3.4.1 PF11_0352
    PF14_0694
    MAL8P1.17
    PFI0950w
    PF13_0272
  Oxidoreductin (Ero1p)   PF11_0251