Table 1 Enzymes and proteins involved in redox metabolism and their gene/locus in the P. falciparum genome.
From: Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome
Process | Enzyme/protein | EC number | Gene/locus |
|---|---|---|---|
ROS generation | Fe-superoxide dismutase (possibly an Mn enzyme) | 1.15.1.1 | PF08_0071 MAL6P1.194 |
Glutathione biosynthesis and reccycling | Glutamate-cysteine ligase | 6.3.2.2 | PFI0925w |
Glutathione synthase | 6.3.2.3 | PFE0605c | |
Gluathione reductase | 1.8.1.7 | PF14_0192 | |
Glutathione-S-transferase | 2.5.1.18 | PF14_0187 | |
MRP | PFA0590w PFL1410c | ||
Glutathione utilization | Glutathione-S-transferase | 2.5.1.18 | PF14_0187 |
1-Cys peroxiredoxin | PF08_0131 | ||
Glutaredoxin | PFC0271c | ||
Glutaerdoxin-like protein | MAL6P1.72 | ||
Glutaerdoxin-like protein | PFC0205c | ||
Lactoylglutathione lyase (glyoxalase I) | 4.4.1.5 | PF11_0145 | |
Hydoxyacylglutathione hydrolase (glyoxalase II) | 3.1.2.6 | chr4.gen_37 PFL0285w; | |
Thioredoxin synthesis and recycling | Thioredoxin | MAL13P1.225 | |
PF14_0545 | |||
PFI0790w | |||
PFI1250w | |||
Plasmoredoxin | PFC0165w | ||
Thioredoxin reductase | 1.8.1.9 | PFI1170c | |
Thioredoxin utilization | Peroxiredoxin | MAL7P1.159 | |
Trx peroxidase (TPxP) is a | PF14_0368, 2-cys | ||
2-Cys peroxiredoxin | PFL0725w; 2-cys | ||
Glutathione peroxidase | 1.11.1.9 | PFL0595c | |
Ribonucleotide reductase, small chain | 1.17.4.1 | PF10_0154 | |
PF14_0053 | |||
Oxidative protein folding | Protein-disulfde isomerase | 5.3.4.1 | PF11_0352 |
PF14_0694 | |||
MAL8P1.17 | |||
PFI0950w | |||
PF13_0272 | |||
Oxidoreductin (Ero1p) | PF11_0251 |