Log gametocyte densities over time (mean ± 1 s.e.m.) for untreated (a) and drug-treated (b) mice. In (a) gametocyte densities for mixed R+S infections reflect overall R+S gametocytes, as the PCR assay could not distinguish between these (see text); in (b) all gametocytes are produced by clone R, as clone S was cleared from mixed infections. All data points are based on 5 replicate mice, except for mixed infections in untreated mice in (a): 4 mice on day 11 and 3 mice from day 12 onwards. As the limit of detection was 100 gametocytes per μl blood, y-axes start at 2.