Figure 5

P. falciparum stage sensitivity to AD2646. Parasites at the ring (A), trophozoite (B) and schizonte (C) stages were maintained in the presence of 30 nM (square) or 100 nM (triangle) AD2646 for 24 h30, 11 h and 14 h, respectively. Aliquots were then taken, washed and maintained in culture in the absence (open symbol) or in the presence (full symbol) of the same concentration of analog. Controls were cultures maintained in the absence of drug (full circle) and processed as the treated cultures. Parasitemia and parasite morphology were determined on Giemsa-stained smears at the indicated time. Each value is the mean of two independent experiments.