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Table 1 Cytotoxicity of methylene analogs and PPMP on human MRC-5 cells

From: Anti-Plasmodium activity of ceramide analogs

Compounds IC50 (μM) IC90 (μM) Index of selectivity
AD2646 (-) 4.9 7.5 160
AD2645 (+) 6.1 10.3 161
AD2672 (-) 3.7 5.9 2
AD2730 (-) 6.1 9.9 322
AD2729 (-) 5.8 9.8 22
AD2619 (-) 26.7 42.3 624
PPMP 7.5 12.4 0.8
  1. IC50 and IC90 values are the mean of three independent experiments. The S.E. were within 10% of the mean. (-): D-threo, (+): L-threo. Index of selectivity is defined by the ratio of the IC50 value on MRC-5 cells to that on P. falciparum.