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Table 1 NADP utilizing enzymes Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database and the metabolic function of the enzyme.

From: Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes

Enzyme

EC number

PfID

Peak (HPI)

Metabolic function

3-oxoacy1-[acy1-carrier-protein] reductase

1.1.1.100

PFI1125c

28

Fatty acid synthesis

1-deoxy-D-xylulose-5-phosphate reductoisomerase

1.1.1.267

PF14_0641

30

Isoprenoid metabolism

Isocitrate dehydrogenase (NADP+);

1.1.1.42

PF13_0242

28

TCA cycle

Phosphogluconate dehydrogenase

1.1.1.44

PF14_0520

26

PPP

Glucose-6-phosphate 1-dehydrogenase;

1.1.1.49

PF14_0511

48

PPP

Pyruvate dehydrogenase (acetyltransferring).

1.2.4.1

PF11 0256 PF14 0441

28 28

Pyruvate metabolism

Glutamate dehydrogenase (NADP)

1.4.1.4

PF14 0164 PF14 0286

1 30

Glutamate metabolism

Pyrroline-5-carboxylate reductase

1.5.1.2

MAL13P1.284

18

Proline metabolism

Dihydrofolate reductase

1.5.1.3

PFD0830w

26

Folate synthesis

NAD(P)+ transhydrogenase (B-specific);

1.6.1.1

PF14_0508

32

?

NADPH hemoprotein reductase

1.6.2.4

PFI1140w

13

Flavoprotein reduction

Dihydrolipoamide dehydrogenase

1.8.1.4

PF08 0066 PFL1550w

28 11

Pyruvate metabolism

Dihydrolipoamide S-acetyltransferase;

2.3.1.12

PF10 0407

28

Pyruvate metabolism