Skip to main content

Table 3 NAD+-utilizing enzymes. Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database, the metabolic function of the enzyme.

From: Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes

Enzyme EC number PfID Peak (HPI) Metabolic function
Pyrroline carboxylate reductase 1.5.1.2 MAL13P1.284 18 Methionine polyamine metabolism
Ferrodoxin reductase-like protein 1.7.1.4 PF07_0085 21 Nitrogen metabolism
Glutamate dehydrogenase 1.4.1.2 PF08_0132 20 Glutamine metabolism
Aminomethyltransferase 2.1.2.10 PF13 0345 22 Folate biosynthesis
L-lactate dehydrogenase 1.1.1.27 PF13 0141 22 Glycolysis
Enoyl-acyl carrier reductase 1.3.1.9 MAL6P 1.275 30 Fatty acid synthesis
2-oxoglutarate dehydrogenase el component 1.2.4.2 PF08_0045 30 TCA cycle
Lipoamide dehydrogenase, putative 1.8.1.4 PF08_0066 28 TCA cycle
Pyruvate dehydrogenase El component, ?-subunit 1.2.4.1 PF11_0256 28 Fatty acid synthesis
NADH-cytochrome b5 reductase 1.6.2.2 PF13_0353 32 Electron transport
Malate dehydrogenase, putative 1.1.1.37 MAL6P 1.242 34 Pyruvate metabolism
Glycerol-3-phosphate dehydrogenase 1.1.1.8 PF11 0157 PFL0780w 37 19 Glycolysis; Glycerol metabolism
GDP-mannose 4,6-dehydratase 1.1.1.187 PF08_0077 39 Mannose and fructose metabolism
Inosine-5 '-monophosphate dehydrogenase 1.1.1.205 PFI1020c 12 Purine metabolism
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) 1.2.4.4 PFE0225w 32 Leucine, isoleucine and valine degradation
Nitrate reductase 1.7.1.1 chr13.glm_739 32 Nitrogen metabolism