Table 4 Thiamine diphosphate utilizing enzymes. Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database, the metabolic function of the enzyme.
Enzyme | EC number | PfID | HPI | Metabolic function |
|---|---|---|---|---|
Pyruvate dehydrogenase E1 | 1.2.4.1 | PF11_0256 (a) PF14_0441 (b) | 28 28 | Apicoplast fatty acid synthesis |
Transketolase | 2.2.1.1 | MAL6P1.110 | 17 | Pentose phosphate pathway |
Oxalyl-CoA decarboxylase | 4.1.18 | MAL6P1.231 PFF0945c | 26 NA | Glyoxylate and dicarboxylate metabolism |
1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | PF13_0207 | 21 | Isoprenoid biosynthesis |
3-methyl-2-oxobutanoate dehydrogenase | 1.2.4.4 | PFE0225w | 32 | Leucine, isoleucine and valine degradation |
Oxoglutarate dehydrogenase | 1.2.4.2 | PF08_0045 | 32 | Mitochondrial TCA cycle |