Table 2 Associations with pre-treatment gametocytemia in 126 Ghanaian children with uncomplicated malaria
From: Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana
Factor | Prevalence of gametocytemia (%) | Odds ratio (95%CI) of gametocytemia | |||
|---|---|---|---|---|---|
Unadjusted | P | Multivariate | P | ||
CQ in blood | |||||
None | 27.9 (12/43) | 1 | 1 | ||
Present | 14.5 (12/83) | 0.4 (0.2–1.2) | 0.07 | 0.3 (0.1–1.0) | 0.04 |
Ax. temperature | n.a. | 0.3 (0.1–0.6) | 0.0008 | 0.2 (0.1–0.5) | 0.0009 |
Parasite density | |||||
< 50,000/μL | 26.3 (20/76) | 1 | 1 | ||
≥ 50,000/μL | 8.0 (4/50) | 0.2 (0.1–0.8) | 0.01 | 0.2 (0.1–0.8) | 0.02 |
dhfr triple mutation | |||||
Absent | 10.4 (7/67) | 1 | 1 | ||
Present | 28.8 (17/59) | 3.5 (1.2–10.2) | 0.009 | 3.2 (1.0–10.4) | 0.049 |
crt 76 mutation | |||||
Absent | 4.0 (1/25) | 1 | 1 | ||
Present | 22.8 (23/101) | 7.1 (1.0–304) | 0.04 | 14.5 (1.4–150.8) | 0.02 |