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Table 2 Sulfadoxine-pyrimethamine treatment outcomes

From: Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies

Results

no. of included patients

LF and corr.

Evaluable patients

ACPR

n (%)

ETF

n (%)

LCF

n (%)

Total CF

n (%)

LPF

n (%)

Overall TF

n (%)

At D14

         

Ipinda

73

1

72

62(86.1)

7(9.7)

2(2.8)

9(12.5)

1(1.4)

10(13.9)

Mlimba

75

3

72

63(87.5)

3(4.3)

4(5.7)

7(9.1)

2(2.9)

9(12.9)

Mkuranga

93

7

86

71(82.6)

3(3.5)

2(2.3)

5(6.9)

10(11.6)

15(17.4)

Total

241

11

230

196(85.2)

13(5.7)

8(3.5)

21(9.1)

13(5.7)

34(14.9)

At D28

         

Ipinda

72

0

72

44(61.1)

7(9.7)

5(6.9)

12(16.7)

16(22.2)

28(38.9)

Mlimba

72

2

70

34(48.6)

3(4.3)

9(12.9)

12(17.1)

24(34.3)

36(51.4)

Mkuranga

86

0

86

38(44.2)

3(3.5)

12(13.9)

15(17.4)

33(38.4)

48(55.8)

Total

230

2

228

116(50.9)

13(5.7)

26(11.4)

39(17.1)

55(24.1)

112(49.1)

At D28 PCR-corrected

         

Ipinda

72

6

66

44(66.7)

7(9.7)

5(6.9)

12(16.7)

10(13.9)

22(33.3)

Mlimba

70

10

60

34(56.7)

3(4.3)

5(7.1)

8(11.4)

18(25.7)

26(43.3)

Mkuranga

86

11

75

38(50.7)

3(3.5)

8(9.3)

11(12.8)

26(30.2)

37(49.3)

Total

228

27

201

116(57.7)

13(5.7)

18(7.9)

31(13.6)

54(23.7)

85(42.3)

  1. ACPR = Adequate Clinical and Parasitological Response; TF = Treatment failure, ETF = Early Treatment Failure, LCF = Late Clinical Failure; LPF = Late Parasitological Failure; CF = Clinical failure, n = Sample Size; TF = Treatment failure, FP = Lost to Follow-up, corr. = corrected