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Table 1 Comparison of clinical trials to evaluate the efficacy of chloroquine (CQ) + sulfadoxine/pyrimethamine (SP)

From: Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia

Study Location

Year

N

CQ Efficacy

SP Efficacy

CQ + SP Efficacy

Endpoint in Days

Comparison of CQ+SP vs. CQ, CQ+SP vs. SP

Reference

Nigeria

2004

153

n/a

n/a

90%

28

n/a

[30]

Laos

2003

110

n/a

n/a

93%

42

n/a

n/a

[14]

Bangladesh

2002

133

n/a

n/a

72%

28

n/a

[18]

Eastern Uganda

2002

280

n/a

42%

60%

28

n/a

p = ns

[21]

Southern Uganda

2002

448

n/a

70%

83%

14

n/a

p < 0.001

[12]

Western Uganda

2001

141

93%

100%

100%

14

p = ns

p = ns

[13]

Southern Laos

2001

119

55%

82%

83%

14

p = 0.029

p = ns

[19]

Papua, Indonesia

1999

169

17%

79%

62%

28

p < 0.001

p = 0.047

[17]

Southwest Nigeria

1999

111

93%

n/a

96%

28

n/a

p = ns

[22]

Papua New Guinea

1998–1999

513*

n/a

n/a

95%

28

n/a

[3]

The Gambia

1995

405

n/a

90%

95%

28

n/a

p = ns

[20]

Mumbai, India

N/a

49

36%

n/a

87%

42

p < 0.026

n/a

[2]

  1. ns = not significant
  2. n/a = not available
  3. * children were treated with amodiaquine + SP (303 of the 513), ** excluding children