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Table 1 Comparison of clinical trials to evaluate the efficacy of chloroquine (CQ) + sulfadoxine/pyrimethamine (SP)

From: Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia

Study Location Year N CQ Efficacy SP Efficacy CQ + SP Efficacy Endpoint in Days Comparison of CQ+SP vs. CQ, CQ+SP vs. SP Reference
Nigeria 2004 153 n/a n/a 90% 28 n/a [30]
Laos 2003 110 n/a n/a 93% 42 n/a
n/a
[14]
Bangladesh 2002 133 n/a n/a 72% 28 n/a [18]
Eastern Uganda 2002 280 n/a 42% 60% 28 n/a
p = ns
[21]
Southern Uganda 2002 448 n/a 70% 83% 14 n/a
p < 0.001
[12]
Western Uganda 2001 141 93% 100% 100% 14 p = ns
p = ns
[13]
Southern Laos 2001 119 55% 82% 83% 14 p = 0.029
p = ns
[19]
Papua, Indonesia 1999 169 17% 79% 62% 28 p < 0.001
p = 0.047
[17]
Southwest Nigeria 1999 111 93% n/a 96% 28 n/a
p = ns
[22]
Papua New Guinea 1998–1999 513* n/a n/a 95% 28 n/a [3]
The Gambia 1995 405 n/a 90% 95% 28 n/a
p = ns
[20]
Mumbai, India N/a 49 36% n/a 87% 42 p < 0.026
n/a
[2]
  1. ns = not significant
  2. n/a = not available
  3. * children were treated with amodiaquine + SP (303 of the 513), ** excluding children