CQ
|
CQ+SP
|
---|
D
|
N
|
I
|
W
|
IR
|
CIF
|
D
|
N
|
I
|
W
|
IR
|
CIF
|
---|
0
|
26
|
0
|
0
|
0.00
|
0.00
|
0
|
87
|
0
|
0
|
0.00
|
0.00
|
2
|
26
|
0
|
0
|
0.00
|
0.00
|
2
|
87
|
0
|
2
|
0.00
|
0.00
|
4
|
26
|
0
|
0
|
0.00
|
0.00
|
4
|
85
|
1
|
1
|
0.01
|
0.01
|
7
|
26
|
0
|
0
|
0.00
|
0.00
|
7
|
83
|
0
|
0
|
0.00
|
0.01
|
11
|
26
|
1
|
0
|
0.04
|
0.04
|
11
|
83
|
0
|
0
|
0.00
|
0.01
|
14
|
25
|
1
|
1
|
0.04
|
0.08
|
14
|
83
|
0
|
0
|
0.00
|
0.01
|
18
|
23
|
1
|
1
|
0.04
|
0.12
|
18
|
83
|
0
|
2
|
0.00
|
0.01
|
21
|
21
|
1
|
2
|
0.05
|
0.16
|
21
|
81
|
0
|
1
|
0.00
|
0.01
|
28
|
18
|
3
|
0
|
0.17
|
0.30
|
28
|
80
|
0
|
2
|
0.00
|
0.01
|
- N = sample at risk of therapeutic failure at start of interval
- i = the number of cases of therapeutic failure during the interval
- w = the number of subjects withdrawn from the test during the interval due to exclusion from analysis, loss to follow-up after latest blood smear, intercurrent infection with another plasmodia species, or reinfection by different genotype P. falciparum or relapse/reinfection by P. vivax based on day of recurrent parasitemia CQ +DCQ concentrations
- IR = risk of therapeutic failure in the interval, calculated as i/(N-w/2)
- CIF = cumulative incidence of therapeutic failure, calculated as 1-[(1-IRn)(1-CIFn-1)], where IRn is the IR in the current interval and CIFn-1 is the cumulative incidence up to the previous interval