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Table 2 Amino acid variations observed in PfCRT protein in 33 Cambodian isolates and laboratory strains within the phylogenic groups determined by Bayesian analysis. Composition of groups are as follows (laboratory clones and field isolates identified in [18]: group 1: 608, 792, 3D7, HB3; group 2: 738; group 3: 602, 613, 634, 702, 734, 736, 770; group 4: 722, 742; group 5: Dd2, W2, 536, 572, 631, 637, 643, 647, 654, 665, 666, 671, 683, 685, 691, 693, 716, 717, 719, 739, 747, 749, 794.

From: Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure

  Residue numbers    
groups 74 75 76 144 148 194 220 271 326 333 356 371 N IC50 CQ (nM) IC50 FQ (nM)
Group 1 M N K A L I A Q N T I R 4 19.88 (11.4–33.7) 26.59 (7.5–57.6)
Group 2 I D T A I T S E N S I R 1 156.8 37.3
Group 3 I D T F I T S E N S I R 7 95.51 (33.2–169.2) 26.34 (15.7–37)
Group 4 I E T A L I S E N T I I 2 (91.8, 466.7) (38.1, 120.2)
Group 5 I E T A L I S E S T T I 22 149.17 (58.1–674) 39.13 (7.5–115)