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Table 1 Frequency (%) of failure in vivo in antimalarial treatment; Colombia, 1961–2003 (1)

From: Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia

Place, Drug (2) CQ AQ SP Reference
Colombia 82,0    Walker 1968 [38]
Colombia (4) 16,4 28,3 34,7 Blair 1986 [39]
Colombia (5)    24,0 (quoted in Ravreda 2003) [40]
Colombia (5)    25,0 (quoted in Ravreda 2003) [40]
Colombia in vitro 96,0 3,3   Espinal 1985 [41]
Antioquia (state)    34,0 (Restrepo quoted in Ravreda 2003) [40]
El Bagre (Ant ioquia) 82,0 38,0 10,0 Flórez 1988 [42]
El Bagre (Ant ioquia) 71,0 12,0 15,0 López 1999 [27]
Turbo (Ant ioquia) 97,0 7,0 13,0 Blair 1999, 2001 [28, 29]
Zaragoza (Ant ioquia) 67,0 3,0 9,0 Blair 1999, 2002 [28, 30]
Chocó (state) 52,0    Comer 1968 [43]
Quibdó, (Chocó) 44,0    Osorio 1999 [44]
Quibdó, (Chocó)    6,0 Osorio 1999 [44]
Tadó, (Chocó)   27,0 16,0 (González 2002 quoted in Ravreda 2003) [40]
Cali (Valle) 78,0    Castillo 2002 [45]
Buenaventura (Valle)    3,0 Méndez 2002 [46]
Tumaco (Nariño) 70,0 54,0   Flórez 1988 [42]
Tumaco (Nariño) 40,0 18,0 0,0 Flórez 1988 [42]
Tumaco (Nariño)   50,0 15,3 González 2003 [31]
El Charco (Nariño)   0,0 0,0 González 2003 [31]
Orinoquía y Amazonía    (3) Espinal 1985 [41]
Average 66,3 21,9 14,6  
Mean 70,0 19,9 14,6  
  1. (1) Response evaluated in patients (in vivo), except when the contrary has been indicated (in vitro). Duration: approximately from 1961–2003. Blank cells: It was not possible to find information.
  2. (2) AQ amodiaquine, CQ chloroquine, SP sulphadoxine-pyrimethamine, CL clindamicina, MQ mefloquine.
  3. (3) Espinal's report 1985 [41]: it does not mention the amount of failure to SP; it only refers to 3 cases in Orinoquía and 9 in Amazonía.
  4. (4) AQ-CL: Blair 1986 [39] reports one study with 3,8% of failure.
  5. (5) MQ-SP: failure of 0% in 1982 and in 1985; also failure of 0% in Botero et al. 1985 [47]. For MQ: 8.3% of failure in Amazonía.
  6. (6) AQ-SP: González report [31], 11.0% of failure in this place.