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Table 1 Frequency (%) of failure in vivo in antimalarial treatment; Colombia, 1961–2003 (1)

From: Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia

Place, Drug (2)

CQ

AQ

SP

Reference

Colombia

82,0

  

Walker 1968 [38]

Colombia (4)

16,4

28,3

34,7

Blair 1986 [39]

Colombia (5)

  

24,0

(quoted in Ravreda 2003) [40]

Colombia (5)

  

25,0

(quoted in Ravreda 2003) [40]

Colombia in vitro

96,0

3,3

 

Espinal 1985 [41]

Antioquia (state)

  

34,0

(Restrepo quoted in Ravreda 2003) [40]

El Bagre (Ant ioquia)

82,0

38,0

10,0

Flórez 1988 [42]

El Bagre (Ant ioquia)

71,0

12,0

15,0

López 1999 [27]

Turbo (Ant ioquia)

97,0

7,0

13,0

Blair 1999, 2001 [28, 29]

Zaragoza (Ant ioquia)

67,0

3,0

9,0

Blair 1999, 2002 [28, 30]

Chocó (state)

52,0

  

Comer 1968 [43]

Quibdó, (Chocó)

44,0

  

Osorio 1999 [44]

Quibdó, (Chocó)

  

6,0

Osorio 1999 [44]

Tadó, (Chocó)

 

27,0

16,0

(González 2002 quoted in Ravreda 2003) [40]

Cali (Valle)

78,0

  

Castillo 2002 [45]

Buenaventura (Valle)

  

3,0

Méndez 2002 [46]

Tumaco (Nariño)

70,0

54,0

 

Flórez 1988 [42]

Tumaco (Nariño)

40,0

18,0

0,0

Flórez 1988 [42]

Tumaco (Nariño)

 

50,0

15,3

González 2003 [31]

El Charco (Nariño)

 

0,0

0,0

González 2003 [31]

Orinoquía y Amazonía

  

(3)

Espinal 1985 [41]

Average

66,3

21,9

14,6

 

Mean

70,0

19,9

14,6

 
  1. (1) Response evaluated in patients (in vivo), except when the contrary has been indicated (in vitro). Duration: approximately from 1961–2003. Blank cells: It was not possible to find information.
  2. (2) AQ amodiaquine, CQ chloroquine, SP sulphadoxine-pyrimethamine, CL clindamicina, MQ mefloquine.
  3. (3) Espinal's report 1985 [41]: it does not mention the amount of failure to SP; it only refers to 3 cases in Orinoquía and 9 in Amazonía.
  4. (4) AQ-CL: Blair 1986 [39] reports one study with 3,8% of failure.
  5. (5) MQ-SP: failure of 0% in 1982 and in 1985; also failure of 0% in Botero et al. 1985 [47]. For MQ: 8.3% of failure in Amazonía.
  6. (6) AQ-SP: González report [31], 11.0% of failure in this place.