Figure 1

Microsatellite allelic frequencies of pfcrt and putative transporter genes in 27 P. falciparum isolates according to pfcrt 76 allele and chloroquine response phenotype. Microsatellite allelic relative frequencies are given according to pfcrt K76 (wild allele, orange bars) or pfcrt K76T (mutant allele, blue bars) (Figure a, c, e, g and i), or according to inhibitory concentration values (IC₅₀) for chloroquine (susceptible isolates, yellow bars; resistant isolates, green bars) (Figure b, d, f, h and j). The relative frequency of the various allelic forms within each haplotype subgroup is indicated. The microsatellites have either (AAAT)n alleles or (TA)n alleles and they are classified according to the number (n) of repeats. Figure a, b: pfcrt microsatellite in intron 4; Figure c, d: G7 microsatellite; Figure e, f: G25 microsatellite in intron 3; Figure g, h: G25 microsatellite in intron 4; and Figure i, j: G55 microsatellite. Motif 1: TAATATTATAATAT(TA)9T Motif 2: TAATAT(TA)11TMotif 3: TAATAT(TA)10T Motif 4: TAATAT(TA)9T.