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Table 1 Amino acid residue 76 of the pfcrt gene and chloroquine response phenotype of 27 P. falciparum isolates and 3 reference strains.

From: Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa

Isolatesa

CI50bCQ (nM)

pfcrt K76T

Ivory Coast 1

5.3

K

Cameroon 1

13.5

K

Senegal 1

16.8

K

Senegal 2

18.8

K

Senegal 3

23.6

K

Nigeria 1

24.8

K

Congo 1

25.6

T

Madagascar 1

27.3

K

Senegal 4

33.0

K

Madagascar 2

43.4

K

Senegal 5

44.2

T

Mauritania 1

46.6

K

Ivory Coast 2

47.6

T

Madagascar 3

50.0

K

Cameroon 1

52.9

T

Mali 1

53.1

T

Togo 1

60.4

T

the Comoros Island 1

74.5

K

Mali 2

79.6

T

Ivory Coast 3

88.2

T

Ivory Coast 4

99.6

T

Benin 1

100.0

T

Ivory Coast 5

100.0

T

Mali 3

121.0

T

Cameroon 3

169.0

T

Togo 2

173.0

T

Kenya 1

219.0

T

Africa 3D7 strain

18.5

K

Indochina W2 strain

370.0

T

Cameroon FCM29 strain

1105.0

T

  1. aIsolates are designated by the name of their country of origin followed by a number.
  2. bFifty percent inhibitory concentration values : resistance value to chloroquine (CQ) corresponds to IC50>100 nM.