Skip to main content

Table 1 Amino acid residue 76 of the pfcrt gene and chloroquine response phenotype of 27 P. falciparum isolates and 3 reference strains.

From: Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa

Isolatesa CI50bCQ (nM) pfcrt K76T
Ivory Coast 1 5.3 K
Cameroon 1 13.5 K
Senegal 1 16.8 K
Senegal 2 18.8 K
Senegal 3 23.6 K
Nigeria 1 24.8 K
Congo 1 25.6 T
Madagascar 1 27.3 K
Senegal 4 33.0 K
Madagascar 2 43.4 K
Senegal 5 44.2 T
Mauritania 1 46.6 K
Ivory Coast 2 47.6 T
Madagascar 3 50.0 K
Cameroon 1 52.9 T
Mali 1 53.1 T
Togo 1 60.4 T
the Comoros Island 1 74.5 K
Mali 2 79.6 T
Ivory Coast 3 88.2 T
Ivory Coast 4 99.6 T
Benin 1 100.0 T
Ivory Coast 5 100.0 T
Mali 3 121.0 T
Cameroon 3 169.0 T
Togo 2 173.0 T
Kenya 1 219.0 T
Africa 3D7 strain 18.5 K
Indochina W2 strain 370.0 T
Cameroon FCM29 strain 1105.0 T
  1. aIsolates are designated by the name of their country of origin followed by a number.
  2. bFifty percent inhibitory concentration values : resistance value to chloroquine (CQ) corresponds to IC50>100 nM.