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Table 3 Association between polymorphims in pfmdr 1 and 5 putative transporter genes and chloroquine response phenotype and pfcrt 76 mutant allele of 27 P. falciparum isolates.

From: Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa

Gene Predicted product Position AA change Nucleotide change IC50 aCQ pfcrt K76T
pfcrt Transporter 76 K-T AAA-ACA P<.02 -
   220 A-S GCC-TCC P<.05 P<.001
pfmdr1 ABC transporter 86 N-Y AAT-TAT P<.05 P = .37
G25 Sulfate permease Intron   G-A NA NA
G30 GTPase Intron - C-G P = .65 P = .9
G49 ABC/ATPase 146 Q-E CAA-GAA P = .11 P = .9
   1046 K-I AAA-ATA NA NA
   1116 L-I TTA-ATA P = .54 P = .19
G54 Membrane protein 141 Y-Y TAC-TAT P = .58 P = .62
   144 T-T ACG-ACA P = .54 P = .63
G70 Choline transporter 105 E-K GAA-AAA P = .11 P = .9
  1. aFifty percent inhibitory concentration values : resistance value to chloroquine (CQ) corresponds to IC50 > 100 nM
  2. NA for not applicable : no SNP was found in the studied isolates and the reference strains
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Malaria Journal

ISSN: 1475-2875

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