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Table 2 Standard Curves. Functions used to adjust Pyrosequencing allele frequencies for six polymorphic sites in MSP-119.

From: A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa

SNP Location

Function*

Parameter values

a

b

c

d

g

1644

a - dsin(2Ï€p)

-0.00497

-

-

0.0292

-

1691

a+bp+cp2 - dsin(2Ï€p)

0.00894

0.176

-0.170

0.0162

-

1699

bp - dsin(2Ï€p)

-

0.0522

-

0.0261

-

1700

bp + cp2 - dsin(2Ï€p)

-

0.0966

-0.0851

0.0219

-

1701

a+cp2 - dsin(2Ï€p)

-0.0303

-

0.133

0.0223

-

1716

-dsin(2gπp)

-

-

-

0.0311

1.051

  1. *Where p is the allele frequency at the SNP of interest
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Malaria Journal

ISSN: 1475-2875

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