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Table 2 Guidelines for grading severity of adverse events

From: Pharmacovigilance of antimalarial treatment in Africa: is it possible?

Grade Severity Description
1 Mild Awareness of sign or symptom, but easily tolerated: Transient or mild discomfort; no limitation in activity; no medical intervention/therapy required
2 Moderate Discomfort enough to cause interference with usual activity: some assistance may be needed; no or minimal medical intervention required
3 Severe Incapacitating with inability to work or perform usual activity: some assistance usually required; hospitalization possible
4 Life-threatening Extreme limitation in activity, significant assistance required; significant medical intervention/therapy required; hospitalization probable
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