Distribution of CV-CV' values for all domains harboured on PfEMP1 molecules of the 3D7 genome parasite. CV-CV' values computed for all PfEMP1 domains were plotted against domain length. Negative CV-CV' values predict the domain to be soluble, while positive values predict the domain to be insoluble on expression in E. coli. Dashed boxes enclose all domains belonging to a particular domain type. ATS domains are plotted as squares (dark blue), CIDR domains as circles with a central dot (CIDRα – red, CIDR2β – cyan) and DBL domains as solid circles (DBL1α – grey, DBL2β + C2 – green, DBL2-4γ – magenta, DBL2-5δ – grey and DBL2-7ε – yellow).