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Table 3 Final main effects linear model of the association between baseline explanatory variables and day 7 lumefantrine concentration in ng/mL (433 patients).

From: Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda

Variable

Coefficient

95%CI

p-value

p-value (trend)

  

lower

upper

  

referred from hospital OPD (vs. from outlying clinics)

-198.3

-316.9

-63.1

0.005

 

unsupervised treatment

-463.3

-536.8

-381.0

<0.0001

 

age

     

   ≥15 years

[reference]

   

<0.0001

   5–14 years

-54.6

-233.3

158.4

0.591

 

   <5 years

-357.9

-483.8

-208.6

<0.0001

 

lumefantrine dose (mg/Kg)

     

   ≥80

[reference]

   

0.375

   65–79

-168.6

-319.3

9.1

0.062

 

   50–64

-187.5

-348.4

5.1

0.056

 

   <50

-36.1

-287.0

286.8

0.806

 

gametocytaemic at inclusion

395.2

89.5

775.7

0.009

 

history of dizziness at inclusion

-284.4

-414.9

-131.1

0.001

 

constant

     
   

adjusted R2: 0.219

   

p-value for goodness of fit: <0.0001