From: From chloroquine to artemisinin-based combination therapy: the Sudanese experience
Period | Drugs tested | Regions | Protocol used | follow-up (days) | Failure rate (%) | References number |
---|---|---|---|---|---|---|
1975–97 | CQ | central | Standard WHO in-vivo test | 7–28 | 0.8–25.0 | 7, 10 |
eastern | 43.0–48.0 | 8, 9 | ||||
1998–03 | CQ | central | WHO 1996 | 14–28 | 25.0–75.0 | 11, 12 |
eastern | WHO 1996 | 28 | 76.9 | 13 | ||
southern | WHO 1996, EANMAT 1999 | 14–28 | 11.5–93.9 | 14, 15 | ||
north Sudan | WHO 1996 | 14 | 32.0–70.0 | UPD | ||
SP | eastern | WHO 1996 | 28 | 0.0–19.4 | 16, 17 | |
southern | WHO 1996, EANMAT 1999 | 14–28 | 0.0–69.9 | 15, 14 | ||
north Sudan | WHO 1996 | 28 | 1.3–7.8 | UPD | ||
AQ | southern | WHO 1996, EANMAT 1999 | 14 | 5.9–25.2 | 14, 15 | |
MQ | eastern | WHO 1996 | 28 | 7.5 | 20 | |
Q | eastern | WHO 1996 | 28 | 9.4–10.7 | 13 | |
CQ+SP | eastern | WHO 2003 | 28 | 2.5–36.0 | 17, UPD | |
central | WHO 1996 | 28 | 15.5–20.0 | UPD | ||
AS+SP | western | WHO 2003 | 28 | 8.8 | 21 | |
southern | WHO 2003, 1996 | 28–42 | 0.0–0.9 | 22 | ||
central | WHO 2003 | 28 | 0.0 | UPD | ||
AS+AQ | western | WHO 2003 | 28 | 7.3 | 21 | |
southern | WHO 2003, 1996 | 42 | 1.0 | 22 | ||
2004–05 | AS+SP | eastern | WHO 2003 | 28 | 0.0–0.7 | 18, 23 |
southern | WHO 2003, 1996 | 28–42 | 0.0 | 23 | ||
central | WHO 2003 | 28 | 0.0 | 23, 24, UPD | ||
ART+ LUM | southern | WHO 2003 | 28 | 0.0 | UPD | |
central | WHO 2003 | 28 | 0.0 | 24 |