Table 1 Examples of artemisinin-based monotherapies and combinations currently sold in Africa for the treatment of uncomplicated falciparum malaria with summarized informations provided by the manufacturer on the accompanying package insert.
Trade name | Drug substance/s | Tablet strength (mg) | Adult dose/s (mg/day) | Paediatric dose/s (mg/day) | Duration (days) | Tablets/package | Company |
|---|---|---|---|---|---|---|---|
Combination products | |||||||
Artekin – 02 | dihydroartemisinin+ piperaquine | 40/320 | 160/1280 | 7–10 y 80/640 11–15 y 60/480 | 2 | 8 | Hualijian |
Artekin | dihydroartemisinin+ piperaquine | 40/320 | 160/1280 | 7–10 y 80/640 11–15 y 60/480 | 2 | 8 | Holleykin pharmaceutical |
Duo-cotecxin | dihydroartemisinin+ piperaquine | 40/320 | 160/1280 | 7–10 y 80/640 11–15 60/480 | 2 | 8 | Beijing Holley-Cotec |
Coartem | artemether+ lumefantrine | 20/120 | D1 160/960, D2-3 80/480 or D1-3 160/960 | 5–15 kg 40/240 16–25 kg 80/480 26–35 kg 120/720 | 3 | 16–24 | Novartis |
Artequin | artesunate + mefloquine | 200/250 | 200/250 | NA | 3 | 3 + 3 | Mepha |
Arsucam (infants and children) | artesunate + amodiaquine | 50/153 | NA | 1–7 y 50/153 7–13 y 100/306 | 3 3 | 3 + 3 6 + 6 | Sanofi-Aventis |
Arsucam (adults) | artesunate + amodiaquine | 50/153 | 200/612 | NA | 3 | 12 + 12 | Sanofi-Aventis |
Larimal | artesunate + amodiaquine | 50/153 | 200/612 | 4 mg/kg (AS) + 10 mg/kg (AM) | 3 | 12 + 12 | Ipca |
Monotherapies | |||||||
Artesunate tablets | artesunate | 50 | D1 200, D2-5 100 | NA | 5 | 6 | Guilin pharmaceutical |
Arinate | artesunate | 100 | D1 200, D2-5 100 | D1 3.2 mg/kg, D2-5 1.6 mg/kg | 5 | 6 | Dafra |
Arsumax | artesunate | 50 | D1 200, D2-5 100 | D1 4 mg/kg, D2-5 2 mg/kg | 5 | 12 | Sanofi-Aventis |
Cotexin | artesunate | 60 | D1 120, D2-5/7 60 | NA | 5–7 | NA | Cotec |
Artesunate injection | artesunate | 60 | NA | NA | NA | NA | Guilin pharmaceutical |
Arte-biosorp | artesunate | 75 | 300 | NA | 7 | NA | Hovid |
Artenex | artesunate | NA | D1 4tab, D2-5 2tab | D1 3.2 mg/kg, D2-5 2 mg/kg | 5 | 12 | Kinapharma |
Malarin 200 | artesunate | 200 | D1 400, D2-5 200 | D1 4 mg/kg, D2-5 2 mg/kg (infants) D1 200, D2-5 100 (children) | 5 | 6 | tri-health |
Plasmotrim 200 | artesunate | 200 | D1 400, D2-5 200 | NA | 5 | 6 | Mepha |
Plasmotrim 50 | artesunate | 50 | NA | D1 10 mg/kg, D2-5 5 mg/kg | 5 | 12 | Mepha |
Gvither forte kit injection | artemether | 80 | D1 240, D2-5 80 | D1 4 mg/kg, D2-5 2 mg/kg | 5 | 6 | Gvs labs |
Gvither forte tablets | artemether | 80 | D1 240, D2-5 80 | D1 4 mg/kg, D2-5 2 mg/kg | 5 | 6 | Gvs labs |
Larither capsule | artemether | 40 | D1 4 mg/kg, D2-5 2 mg/kg | NA | 7 | 6 | Ipca |
Capsulae artemetheri | artemether | 40 | D1 160, D2-5 80 | NA | 5–7 | 10 | Kunming pharmaceutical |
Arte-biosorp | artemisinin | 75 | 150 | NA | 7 | 30 | Hovid |
Malaxin | dihydroartemisinin | 60 | D1 120, D2-5/7 60 | NA | 7 | 8 | Cho dang pharmaceutical |
Cotecxin | dihydroartemisinin | 60 | D1 120, D2-5/7 60 | D1 60, D2-7 30 | 7 | 8 | Jiaxing nanhu |