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Figure 3 | Malaria Journal

Figure 3

From: Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil

Figure 3

PBMC proliferative response to recombinant proteins VIR and MSP1 19 from individuals recently exposed to P. vivax malaria. PBMC proliferation assay was performed as described in the Methods section. Each recombinant protein VIR, MSP119 or GST was tested in final concentration of 2 and 10 μg/ml. Individuals were considered as positive responders when they showed SI > 2.5 for at least one of the two concentrations of recombinant protein when compared to PBMC cultures containing the GST protein alone (VIR proteins) or medium alone (MSP119). Symbols represent the SI obtained after stimulation with each antigen at the final concentration of 2 μg/ml (A) or 10 μg/ml (B). The horizontal lines represent the SI = 2.5. Individuals never exposed to malaria did not respond to antigen stimulation (data not shown). PBMC were also stimulated with Con A as positive controls. The SI obtained after stimulation with this mitogen varied from 15 to 178.2 (data not shown).

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