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Figure 3 | Malaria Journal

Figure 3

From: Dynamics of immune response and drug resistance in malaria infection

Figure 3

Pharmaco-dynamics of the simple 'growth-treatment' model. The upper-left panel shows maximal parasite reduction (8) as a function of (relative) initial dose D0 for fixed clearing efficiency b = 3 and several decay rates β. The upper right panel shows the corresponding time to attain 'maximal clearing' (lowest parasite density). The lower left panels plot exact solutions x(t) for fixed b = 3, three choices D0 = 2,3,4, and two decay rates β = .2 (thin curves) and β = .1 (thick curves). Only one of them (β = .1; D0 = 4) leads to complete clearing by day 12. The lower right panel compares treatment outcomes of a sensitive strain (thin) and resistant strain (thick) at the decay rate β = .05, with clearing rates b X = .5b Y ; D X = .5D Y .

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