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Table 1 Mean IC50 values for chloroquine and pyrimethamine determined by the PicoGreen® or [3H]-hypoxanthine accumulation assay. Mean IC50 values for chloroquine and pyrimethamine were determined by the PicoGreen® or the [3H]-hypoxanthine accumulation assay for two laboratory lines of P. falciparum, 3D7 and K1. Data are the means of 3 independent determinations and standard error of the mean (s.e.m.) values are given in brackets. P-values were obtained from Student's t-test comparisons of IC50 values obtained for the two methods.

From: An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro

Parasite Mean IC50 values in nM (s.e.m.)  
Drug PicoGreen [ 3 H]-hypoxanthine P-value
3D7
   Chloroquine 6.3 (0.4) 7.2 (1.1) 0.47
   Pyrimethamine 38.6 (7.6) 47.4 (9.6) 0.51
K1
   Chloroquine 141 (29.4) 128 (7.4) 0.69
   Pyrimethamine 295 (115.2) 437 (133.4) 0.47