Distribution of total IgE levels per clinical group in both studied populations: Gabon and India. A. Total IgE levels (μg/ml) per clinical group in Gabonese patients (non-significant Kruskall Wallis test). B. Total IgE levels (μg/ml) in Indian patients (significant Kruskall Wallis test, p = 0.0005). C. Percentage of patients with defined IgE levels per group in the Gabonese population (normal levels (N) lower than or equal to 0.500 μg/ml, moderate levels (N to 2N), from 0.501 to 1.000 μg/ml, high levels (2N to 3N), from 1,000 to 1,500 μg/ml, very high (>3N) greater than 1,500 μg/ml). D. Percentage of patients with defined levels of IgE per group in the Indian population (normal levels (N) lower than or equal to 4,000 μg/ml, moderate levels (N to 2N), from 4,000 to 8,000 μg/ml, high levels (2N to 3N), from 8,000 to 12,000 μg/ml, very high (>3N), greater than 12,000 μg/ml). Legend: EC – endemic control, AI – Asymptomatic infected, UM – uncomplicated malaria, SM – severe malaria, CM – cerebral malaria, NEC – non-endemic control, ExCM – ex-cerebral malaria.