Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use

Table 3 Efficacy of antimicrobial preservation of the artemisinin-derivative reconstituted suspensions

	pH wet suspension	Preservative	P. aeruginosa	S. aureus	E. coli	C. albicans	Z. rouxii	A. niger	Ph. Eur. requirements
Artenam^®	4.50	Sorbic acid	-	-	-	-	-	-	Conforms
Gvither^®	4.30	MP/PP	-	-	-	-	-	-	Conforms
Artesiane^®	5.43	MP/PP	-	-	-	-	-	+	Does not conform
Alaxin^®	4.40	MP/PP	-	+	-	-	-	+	Does not conform
Artexin^®	5.90	Benzoic acid	+	-	+	-	-	-	Does not conform
Santecxin^®	5.55	Benzoic acid	+	-	+	+	+	+	Does not conform
Cotecxin^®	not tested	Chlorbutanol?	-	-	+	+	+	+	Does not conform

+ = positive for the tested microorganisms, - = negative for the tested microorganisms
MP = methylparaben, PP = propylparaben

ISSN: 1475-2875