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Table 2 Morbidity and mortality among HIV-infected and HIV-uninfected children <5 years old with severe malarial anaemia

From: The effect of HIV on morbidity and mortality in children with severe malarial anaemia

  HIV infected children (N = 78) Years of follow-up = 5.2 HIV uninfected children (N = 769) Years of follow-up = 55.0 † Hazard ratio (HR) or Incidence rate ratio (IRR) P-value
In the 28 days following first admission with severe malarial anaemia Episodes or Deaths Rate per 100 person-years Episodes or Deaths Rate per 100 person-Years   
Mortality       
Death within 7 days of a malaria episode 8 153.8 28 50.9 2.86 (1.30 – 6.29) 0.009
Death within 28 days of a malaria episode 12 230.8 33 60.0 3.70 (1.91 – 7.17) <0.001
Hospital admissions       
Any reason for re-admission 11 211.5 28 50.9 4.05 (1.95 – 8.43) <0.001
Re-admission due to malaria 5 96.2 13 23.6 3.74 (1.41 – 9.90) 0.008
In the 6 months follow-up (Includes repeat episodes)       
Mortality       
All cause mortality 26 110.2 50 17.8 5.70 (3.54 – 9.16) <0.001
Death within 7 days of any malaria episode 12 50.8 33 11.7 3.74 (1.93 – 7.26) <0.001
Death within 28 days of any malaria episode 19 80.5 41 14.6 4.88 (2.83 – 8.42) <0.001
Hospital admissions       
Any reason for re-admission 18 76.3 66 23.5 2.93 (1.62 – 5.29) <0.001
Re-admissions due to malaria 7 29.7 26 9.2 2.66 (1.17 – 6.07) 0.02
Malaria incidence       
Malaria diagnosed during visits after enrollment 92 394.1 881 313.9 1.12 (0.91 – 1.38) 0.273
Malaria episode >28 days after last malaria episode 54 228.8 582 206.9 0.98 (0.76 – 1.28) 0.895
Unscheduled visits       
Unscheduled visits to the clinic 24 101.7 227 80.7 1.14 (0.74 – 1.77) 0.543
  1. † Adjusted for age, sex and baseline quinine treatment status