Table 2 Morbidity and mortality among HIV-infected and HIV-uninfected children <5 years old with severe malarial anaemia
From: The effect of HIV on morbidity and mortality in children with severe malarial anaemia
HIV infected children (N = 78) Years of follow-up = 5.2 | HIV uninfected children (N = 769) Years of follow-up = 55.0 | † Hazard ratio (HR) or Incidence rate ratio (IRR) | P-value | |||
|---|---|---|---|---|---|---|
In the 28 days following first admission with severe malarial anaemia | Episodes or Deaths | Rate per 100 person-years | Episodes or Deaths | Rate per 100 person-Years | ||
Mortality | ||||||
Death within 7 days of a malaria episode | 8 | 153.8 | 28 | 50.9 | 2.86 (1.30 – 6.29) | 0.009 |
Death within 28 days of a malaria episode | 12 | 230.8 | 33 | 60.0 | 3.70 (1.91 – 7.17) | <0.001 |
Hospital admissions | ||||||
Any reason for re-admission | 11 | 211.5 | 28 | 50.9 | 4.05 (1.95 – 8.43) | <0.001 |
Re-admission due to malaria | 5 | 96.2 | 13 | 23.6 | 3.74 (1.41 – 9.90) | 0.008 |
In the 6 months follow-up (Includes repeat episodes) | ||||||
Mortality | ||||||
All cause mortality | 26 | 110.2 | 50 | 17.8 | 5.70 (3.54 – 9.16) | <0.001 |
Death within 7 days of any malaria episode | 12 | 50.8 | 33 | 11.7 | 3.74 (1.93 – 7.26) | <0.001 |
Death within 28 days of any malaria episode | 19 | 80.5 | 41 | 14.6 | 4.88 (2.83 – 8.42) | <0.001 |
Hospital admissions | ||||||
Any reason for re-admission | 18 | 76.3 | 66 | 23.5 | 2.93 (1.62 – 5.29) | <0.001 |
Re-admissions due to malaria | 7 | 29.7 | 26 | 9.2 | 2.66 (1.17 – 6.07) | 0.02 |
Malaria incidence | ||||||
Malaria diagnosed during visits after enrollment | 92 | 394.1 | 881 | 313.9 | 1.12 (0.91 – 1.38) | 0.273 |
Malaria episode >28 days after last malaria episode | 54 | 228.8 | 582 | 206.9 | 0.98 (0.76 – 1.28) | 0.895 |
Unscheduled visits | ||||||
Unscheduled visits to the clinic | 24 | 101.7 | 227 | 80.7 | 1.14 (0.74 – 1.77) | 0.543 |