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Table 2 Comparison of Least Squares (Predicted) Means by Category, Controlled for Covariates (age, sex and parasitemia) For Biomarkers Showing Overall Statistically Significant Differences between the three Study Groups

From: Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children

BIOMARKER

OVERALL P VALUE

P VALUE FOR PAIRED GROUPS

  

CM vs. NM

CM vs. SMA

SMA vs. NM

Serum IP-10

0.005

0.002

0.001

NSS

CSF IP-10

0.005

0.001

0.004

NSS

CSF IL-8

0.0005

0.0001

0.001

NSS

CSF MIP-1β

0.0005

0.0001

0.001

NSS

CSF PDGFbb

0.008

0.0002

0.01

NSS

CSF IL-1ra

0.002

0.0004

0.005

NSS

CSF Fas-L

0.04

0.002

NSS

NSS

CSF sTNF-R1

0.0001

0.00001

0.0002

NSS

CSF sTNF-R2

0.001

0.0001

0.002

NSS

  1. Statistically significant differences in biomarkers between the three disease groups determined by multivariate analyses [Comparison of Least Squares (Predicted) with Bonferonni correction] after modeling and controlling for covariates (age, sex, and parasitemia); P < 0.05 considered statistically significant; NSS, not statistically significant.