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Table 1 Frequency distribution of mutations conferring resistance to chloroquine and pyrimethamine-sulphadoxine in Plasmodium falciparum isolates from southeastern Iran

From: Prevalence of mutations associated with antimalarial drugs in Plasmodium falciparum isolates prior to the introduction of sulphadoxine-pyrimethamine as first-line treatment in Iran

 

Gene

Codon

Chabahar (n = 152)

Sarbaz (n = 54)

   

Mutation (%)

Mutation (%)

Choloroquine

pfcrt

76T

149 (98%)

53 (98%)

 

pfmdr 1

86Y

63 (41.4%)

15 (27.7%)

  

86N/Y

1 (0.77%)

1 (1.96%)

Pyrimethamine

pfdhfr

51I

1 (0.77%)

1 (1.96%)

  

59R

150 (98.6%)

53 (98%)

  

108N

152 (100%)

54 (100%)

  

108T

-

-

  

164L

-

-

Sulphadoxine

pfdhps

436A

-

-

  

436F

-

-

  

437G

26 (17%)

18 (33%)

  

437A/G

3 (1.9%)

3 (5.5%)

  

540E

-

-

  

581G

-

-

  

613N

-

-