Table 2 The frequency distribution of SNPs combinations of pfcrt and pfmdr1 associated to chloroquine resistance, plus pfdhfr and pfdhps alleles associated with pyrimethamine-sulphadoxine resistance in clinical isolates of Plasmodium falciparum in southeastern Iran
Gene | Codon/Mutation | Chabahar | Sarbaz | Total |
|---|---|---|---|---|
| Â | Â | n = 152 | n = 54 | n = 206 |
pfcrt + pfmdr 1 | 76T + 86Y | 63 (41.4%) | 16 (29.6%) | 79 (38.3%) |
Pfdhfr | 59R + 108N | 150 (98.7%) | 53 (98%) | 203 (98.5%) |
Pfdhfr | 51I + 59R + 108N | 1 (0.77%) | 1 (1.96%) | 2 (1.1%) |
Pfdhfr + pfdhps | 59R + 108N + 437G | 24 (15.8%) | 18 (35.3%) | 42 (20.4%) |
pfcrt + pfmdr 1 + pfdhfr + pfdhps | 76T + 86Y + 59R + 108N +437G | 13 (8.55%) | 9 (17.6%) | 22 (10.7%) |