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Table 5 Clinical laboratory values on D0 (pre-treatment), Day 7 and Day 28 (mean, standard deviation) and mean (95CI) changes between Day 0 and Day 28

From: Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal

     

Difference vs. D0

  

N

mean

std dev

N

Mean

95% CI

Paired t-test

Haematocrit

D 0

323

39

6

     
 

D 7

233

36.3

5.6

228

-2.5

-3.2

-1.8

<.0001

 

D 28

171

38.8

5

168

-0.3

-1.2

0.6

0.51

WBCs

D 0

212

6421

2929

     
 

D 7

120

6746

2509

120

-78.9

-602.6

444.8

0.76

 

D 28

88

6987

2598

86

395.5

-234.8

1026

0.22

ASAT

D 0

167

40.2

38.8

     
 

D 7

134

23

41

123

-7.4

-14.4

-0.3

0.04

 

D 28

106

21

22

101

-15.2

-22.1

-8.3

<.0001

ALAT

D 0

169

21.4

16.3

     
 

D 7

133

15

29.9

126

-4

-9.2

1.1

0.12

 

D 28

105

11.7

11.7

103

-9.4

-12.7

-6.2

<.0001

Creatinine

D 0

166

0.6

0.3

     
 

D 7

132

0.8

1.4

118

0.2

-0.1

0.4

0.23

 

D 28

106

0.7

0.3

100

0.1

0

0.2

0.02

Bilirubin

D 0

156

7

6.2

     
 

D 7

123

3.3

2.2

104

-3.9

-5

-2.8

<.0001

 

D 28

75

4.2

4.3

71

-3.4

-5.1

-1.6

0.0004

  1. D0 = pre-treatment.
  2. std dev = Standard Deviation.
  3. 95% CI = Confidence Interval at 95% level for estimated mean change