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Table 2 Frequency of P. falciparum polymorphisms in dhfr, dhps and crt genes in relation to treatment outcome

From: Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum

SP Haplotypes TF ACPR
N   34 16
dhfr    
wildtype CNCS 0 2
S108N, single CNCN 1 1
C59R + S108N, double CNRN 1 1
N51I + S108N, double CICN 3 3
N51I + C59R + S108N, triple CIRN 28 8
Mixed*   1 1
dhps    
wildtype SAKAA/AAKAA 18 11
A437G, single SGKAA 5 0
A437G + K540E, double SGEAA 11 4
single-double combined   16 4
Mixed*   0 1
dhfr-dhps    
triple-double   10 3
triple-single   4 0
double-double   1 1
AQ   TF ACPR
N   19 31
76K CVNMK 3 12
76T CVIET 16 18
Mixed*   0 1
  1. TF: Parasitological or clinical treatment failure, ACPR: Adequate clinical and parasitological response. SP: sulphadoxine-pyrimethamine, AQ: amodiaquine. Haplotypes defined as amino acid sequences based on the following substitutions in dhfr: S108N (single), C59R + S108N or N51I + C59R (double) and N51I + C59R + S108N (triple), and in dhps: A437G (single) and A437G + K540E (double) were assessed. For the crt gene, the K76T amino acid substitution was assessed. *Classified as mixed when none of the haplotypes were dominant.