Sequence diversity and natural selection at domain I of the apical membrane antigen 1 among Indian Plasmodium falciparum populations

Table 1 Measures of DNA sequence polymorphisms and tests of neutrality at domain I of AMA 1 among Indian P. falciparum populations

Study areas (n = 157)	Segregating sites (S)	Singleton variable sites	Parsimony informative sites	Total no. of mutations	K	H	Hd ± S.D	π ± S.D	dN-dS ± S.E	Tajima's D
Assam (n = 28)	34	6	28	38	10.97	20	0.971 ± 0.018	0.0240 ± 0.0009	0.029 ± 0.006	0.461
Orissa (n = 35)	35	5	30	40	9.96	23	0.948 ± 0.025	0.0218 ± 0.0015	0.027 ± 0.005	0.094
A & N (n = 40)	34	6	28	35	10.34	18	0.926 ± 0.022	0.0226 ± 0.0008	0.027 ± 0.007	0.895
UP (n = 36)	24	6	18	26	7.31	10	0.748 ± 0.066	0.0160 ± 0.0014	0.020 ± 0.005	0.576
Goa (n = 18)	19	1	18	20	8.07	7	0.882 ± 0.039	0.0177 ± 0.0011	0.023 ± 0.006	1.518
Total (n = 157)	44	8	36		10.13	57	0.948 ± 0.010	0.0222 ± 0.0005	0.027 ± 0.006	0.429

n; number of isolates, S; Number of segregating (polymorphic/variable) sites; K; Average number of pairwise nucleotide differences, H; Number of haplotypes, Hd; Haplotype diversity; π; Observed average pairwise nucleotide diversity; dN-dS; rate of non-synonymous mutations minus rate of synonymous mutations; D; Tajima's D test statistics.

ISSN: 1475-2875