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Table 3 Generalized linear model (SAS System Proc Genmod) of chloroquine (CQ), monodesethylamodiaquine (MdAQ), quinine (QN) and artemisinin (ART) IC50 (nM) with the year as independent parameter (loge-transformed values and 1997 as the reference value).

From: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

   CQ MdAQ QN ART
Parameter   Estimate Std Error p Estimate Std Error p Estimate Std Error p Estimate Std Error p
Intercept   4.9 0.2 <.0001 2.1 0.1 <.0001 5.2 0.1 <.0001 1.2 0.3 <.0001
year* 2000 -0.5 0.3 N.S. 1.6 0.2 <.0001 0.3 0.2 N.S. 0.5 0.3 N.S.
  2001 0.1 0.3 N.S. 1.5 0.2 <.0001 0.7 0.2 0.0003 0.1 0.3 N.S.
  2002 -0.3 0.2 N.S. 1.4 0.2 <.0001 -0.1 0.2 N.S. 0.1 0.3 N.S.
  2003 -0.1 0.3 N.S. 1.1 0.2 <.0001 0.3 0.2 N.S. 0.6 0.3 N.S.
  2004 -0.1 0.2 N.S. 0.6 0.2 0.0001 -0.1 0.2 N.S. 0.5 0.3 N.S.
Scale   1.1 0.0 - 0.8 0.0 - 0.8 0.0 - 0.8 0.0 -