Table 3 Generalized linear model (SAS System Proc Genmod) of chloroquine (CQ), monodesethylamodiaquine (MdAQ), quinine (QN) and artemisinin (ART) IC50 (nM) with the year as independent parameter (loge-transformed values and 1997 as the reference value).
CQ | MdAQ | QN | ART | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Estimate | Std Error | p | Estimate | Std Error | p | Estimate | Std Error | p | Estimate | Std Error | p | |
Intercept | 4.9 | 0.2 | <.0001 | 2.1 | 0.1 | <.0001 | 5.2 | 0.1 | <.0001 | 1.2 | 0.3 | <.0001 | |
year* | 2000 | -0.5 | 0.3 | N.S. | 1.6 | 0.2 | <.0001 | 0.3 | 0.2 | N.S. | 0.5 | 0.3 | N.S. |
2001 | 0.1 | 0.3 | N.S. | 1.5 | 0.2 | <.0001 | 0.7 | 0.2 | 0.0003 | 0.1 | 0.3 | N.S. | |
2002 | -0.3 | 0.2 | N.S. | 1.4 | 0.2 | <.0001 | -0.1 | 0.2 | N.S. | 0.1 | 0.3 | N.S. | |
2003 | -0.1 | 0.3 | N.S. | 1.1 | 0.2 | <.0001 | 0.3 | 0.2 | N.S. | 0.6 | 0.3 | N.S. | |
2004 | -0.1 | 0.2 | N.S. | 0.6 | 0.2 | 0.0001 | -0.1 | 0.2 | N.S. | 0.5 | 0.3 | N.S. | |
Scale | 1.1 | 0.0 | - | 0.8 | 0.0 | - | 0.8 | 0.0 | - | 0.8 | 0.0 | - | |