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Table 4 IC50s for chloroquine (CQ) quinine (QN), monodesethylamodiaquine (MdAQ) and artemisinin (ART) in nM. Geometric Least Squares Means Ratio between years.

From: Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

   MdAQ CQ QN ART
Variable 2 one-sided 90% limits GLS Mean Ratio (%) 90%CI 2sided t p-value GLS Mean Ratio (%) 90%CI 2sided t p-value GLS Mean Ratio (%) 90%CI 2sided t-value GLS Mean Ratio (%) 90%CI 2sided t p-value
1997 vs 2000 [80,125] 516.7 [266.4,1002.3] <0.0001 63.2 [25.5,156.7] N.S. 131.4 [69.3,249.2] N.S. 166.8 [57.2,486.0] N.S.
1997 vs 2001 [80,125] 452.3 [230.3,888.2] <0.0001 113.5 [45.1,285.4] N.S. 193.1 [103.8,359.2] 0.005 110.9 [38.0,323.0] N.S.
1997 vs 2002 [80,125] 388.2 [209.6,719.2] <0.0001 71.3 [30.7,165.8] N.S. 92.9 [52.1,165.4] N.S. 110.8 [39.2,313.4] N.S.
1997 vs 2003 [80,125] 297.1 [154.0,573.0] <0.0001 86.2 [35.0,212.3] N.S. 135.1 [73.9,247.2] N.S. 175.6 [61.0,505.7] N.S.
1997 vs 2004 [80,125] 186.3 [106.1,326.9] 0.003 88.0 [40.0,193.5] N.S. 89.5 [52.8,151.6] N.S. 172.5 [60.3,493.5] N.S.
2000 vs 2001 [80,125] 87.5 [42.5,180.4] N.S. 179.6 [72.4,445.3] N.S. 147.0 [73.3,294.9] N.S. 66.5 [31.5,140.3] N.S.
2000 vs 2002 [80,125] 75.1 [38.5,146.7] N.S. 112.9 [49.3,258.3] N.S. 70.7 [36.6,136.5] N.S. 66.4 [32.9,134.2] N.S.
2000 vs 2003 [80,125] 57.5 [28.4,116.5] N.S. 136.4 [56.1,331.1] N.S. 102.9 [52.0,203.3] N.S. 105.3 [50.7,218.5] N.S.
2000 vs 2004 [80,125] 36.1 [19.4,67.0] <0.0001 139.2 [64.3,301.2] N.S. 68.1 [36.8,125.9] N.S. 103.4 [50.3,212.5] N.S.
2001 vs 2002 [80,125] 85.8 [43.4,169.6] N.S. 62.8 [27.0,146.1] N.S. 48.1 [25.4,91.1] 0.002 100.0 [49.4,202.0] N.S.
2001 vs 2003 [80,125] 65.7 [32.0,134.7] N.S. 75.9 [30.8,187.0] N.S. 70.0 [36.0,135.8] N.S. 158.4 [76.3,328.7] N.S.
2001 vs 2004 [80,125] 41.2 [21.9,77.5] 0.000 77.5 [35.2,170.5] N.S. 46.3 [25.6,83.9] <0.0001 155.6 [75.7,319.8] N.S.
2002 vs 2003 [80,125] 76.5 [39.4,148.6] N.S. 120.8 [53.2,274.6] N.S. 145.5 [78.0,271.2] N.S. 158.5 [79.8,314.7] N.S.
2002 vs 2004 [80,125] 48.0 [27.1,84.8] <0.0001 123.3 [61.5,247.2] N.S. 96.3 [55.7,166.8] N.S. 155.7 [79.2,305.9] N.S.
2003 vs 2004 [80,125] 62.7 [33.9,115.8] N.S. 102.1 [47.5,219.2] N.S. 66.2 [37.2,117.9] N.S. 98.2 [48.6,198.4] N.S.