Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa

Table 4 Serious adverse events by treatment group

	CQ (N = 79)	SP (N = 77)	SP – AS (N = 81)
Patients with any SAE, n (%)	15 (19.0)	10 (13.0)	3 (3.7)^‡
- Severe anaemia	3	2	0
- Acute respiration infection	2	2	3
- Seizure	1	1	0
- Pyomyositis	0	1	0

(% calculated on the total number of patients). ‡ Comparison using Fisher's Exact test for SP-AS vs CQ (p = 0.002) and SP-AS vs SP (p = 0.043)

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