Figure 1
From: Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection
Bone marrow chimeric mice with CD36 expression confined to lethal radiation-sensitive cells are partially protected from CM. (A) Cumulative survival and parasitaemias (C) of CD36+/+ into CD36+/+ (n = 11) and CD36-/- into CD36+/+ (n = 11) through the course of P. berghei ANKA infection. (B) Cumulative survival and parasitaemias (D) of CD36+/+ into CD36-/- (n = 31) and CD36-/- into CD36-/- (n = 18) through the course of P. berghei ANKA infection. Survival curves represent the summary of four of independent experiments. Parasitaemia curves are from one representative experiment out of the four performed. In two independent experiments, CD36+/+bmCD36-/- and CD36-/-bmCD36+/+ were generated and infected at same time. LOG-RANK Test: P < .001 for curve (B). ● CD36+/+ into CD36+/+, ○ CD36-/- into CD36+/+, ◆ CD36-/- into CD36-/-, ◇ CD36+/+ into CD36-/-. Gray area represents the time window for ECM development.