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Table 4 Intronic haplotype frequencies for pfcrt-SVMNT and CVIET samplesa

From: Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea

 

Early 1980's

Post-1995

 

Community

Clinical

 

Liksul

Dreikikir

Wosera

Wosera

Haplotype

(msint2_msint3)

SVMNT

nb = 6

SVMNT

n = 22

SVMNT

n = 21

SVMNT

n = 88

SVMNT

n = 82

CVIET

n = 6

3_8

0.667

0.955

0.667 c

0.898

0.951

0

7_8

0

0.045

0.095

0.057

0.037

0

8_3

0.167

0

0

0

0

0

3_2

0.167

0

0

0

0

0

7_4

0

0

0.048

0

0

0

3_3

0

0

0.048

0

0

0

3_6

0

0

0.048

0

0

0

6_6

0

0

0.048

0

0

0

10_8

0

0

0.048

0

0

0

8_8

0

0

0

0.023

0

0

9_8

0

0

0

0.011

0

0

2_8

0

0

0

0.011

0

0.500

4_8

0

0

0

0

0.012

0

1_8

0

0

0

0

0

0.333

8_7

0

0

0

0

0

0.167

  1. a Total number of samples 215: early 1980's (6), Liksul (21), Dreikikir (16), Wosera community samples (85), Wosera clinical samples (81 SVMNT, 6 CVIET).
  2. b "n" indicates the number of haplotype infections present, which may or may not be equal to the total number of samples due to mixed haplotypes in some samples. Overall, 225 haplotypes were found in 215 samples.
  3. c Frequencies in bold indicate that the haplotype was also observed in the CQS samples from that region.