Table 5 Methodological differences in the estimation of antimalarial resistance; the highest EC50 (ng/mL) (Brockman et al, 2000)
Isolate | Range of concentrations tested (ng/mL) | EC 50 Standard estimate | EC 50 "Bayesian" estimate | Overestimation by standard method (%) |
|---|---|---|---|---|
Artesunate (A) | 0.52 – 33.46 | 23.4 | 20.3 | 15% |
Halofantrine (B) | 1.02 – 65.32 | 51.8 | 41.2 | 26% |
Mefloquine (C) | 3.59 – 230 | 195 | 138 | 41% |
Mefloquine (D) | 3.59 – 230 | 197 | 138 | 43% |
Chloroquine (E) | 21.44 – 1,372 | 1065 | 801 | 32% |
Chloroquine (F) | 21.44 – 683 | 536 | 420 | 32% |