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Table 3 Prevalence of pfcrt and pfmdr1 alleles in post-treatment samples of Nigerian children with acute uncomplicated malaria.

From: Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria

Allele Frequency Treatment outcome (%)  
   Cured N = 72 Failed N = 44 P. value
N = 116     
Pfcrt T 76 86 (74%) 51 (71%) 41 (93%)  
Pfcrt K 76 11 (12%) 11 (15%) 0 (0%) 0.003*
T76+K76 19 (14%) 10 (14%) 9 (20%)  
N = 116     
Pfmdr1 Y86 34 (29%) 22 (31%) 12 (27%)  
Pfmdr1 N86 74 (64%) 47 (65%) 27 (61%) n.s.
Y86+N86 8 (7%) 3 (4%) 5 (11%)  
N = 116     
Pfmdr1 F184 74 (64%) 45 (63%) 29(65%)  
Pfmdr1 Y 184 35 (30%) 24 (33%) 11 (25%) n.s.
F184+Y184 7 (6%) 3 (4%) 4 (9%)  
N = 116     
T76 + Y86 37 (32%) 21 (29%) 16 (36%)  
K76 + N86 7 (6%) 7 (10%) 0 (0%) 0.028*
Mixed 72 (62%) 44 (61%) 28 (64%)  
N = 116     
T76 + F186 73 (63%) 40 (56%) 33 (75%)  
K76 + Y184 2 (2%) 2 (3%) 0 (0%) n.s.
Mixed 41 (35%) 30 (42%) 11 (25%)  
N = 116     
T76+Y86+F184 35 (30%) 19 (26%) 16 (36%)  
K76+N86+Y184 3 (3%) 3 (4%) 0 (0%) n.s.
Mixed 78 (67%) 50 (70%) 28 (64%)  
  1. n.s. is not significant