Table 1 Characteristics at admission of 83 children requiring endotracheal intubation for severe Plasmodium falciparum malaria in Dakar, Senegal, according to vital status
From: Outcome of life-threatening malaria in African children requiring endotracheal intubation
Parameter | Survivors (n = 33) | Non Survivors (n = 50) | P value |
|---|---|---|---|
Male | 22 (66.6) | 29 (58.0) | 0.49 |
Median age, years | 9 (7 – 12) | 9 (5 – 12) | 0.70 |
Median time to admission, days | 2 (1 – 3) | 3 (2 – 5) | 0.03 |
Duration of coma before intubation, hrs | 13 (6 – 28) | 11 (1 – 27) | 0.21 |
Previous antimalaric treatment | 22 (66.6) | 28 (56.0) | 0.37 |
PRISMh24 | 11 (6 – 18) | 15 (11 – 20) | 0.05 |
Number of Organ dysfunctions | 2 (2 – 3) | 2 (2 – 3) | 0.24 |
PELODh24 | 11 (2 – 21) | 12. 5 (11 – 22) | 0.02 |
Blantyre Coma Score | 3 (1 – 3) | 2 (3 – 4) | 0.05 |
Glasgow Coma Score | 8 (7 – 9) | 7 (9 – 11) | 0.03 |
Highest temperature, °C | 39.0 (38.6 – 39.8) | 39.0 (37.9 – 40.0) | 0.32 |
Heart pulse rate,/min | 132 (120 – 151) | 136 (116 – 160) | 0.48 |
Respiratory rate,/min | 35 (25 – 46) | 44 (36 – 52) | 0.09 |
Mean arterial blood pressure, mmHg | 73 (63 – 83) | 67 (60 – 77) | 0.05 |
Systolic arterial blood pressure, mmHg | 100 (90 – 110) | 90 (80 – 100) | 0.09 |
Diastolic arterial blood pressure, mmHg | 60 (50 – 70) | 50 (50 – 60) | 0.05 |
Arterial pH, pH unit | 7.31 (7.25 – 7.37) | 7.33 (7.20 – 7.40) | 0.78 |
Bicarbonate level, mM | 16.8 (14.8 – 19.2) | 15.0 (11.5 – 17.8) | 0.09 |
PCO2 level, Torr | 34.5 (27 – 40.3) | 29 (25 – 33) | 0.04 |
Haemoglobin, g/dL | 8.4 (6.4 – 9.9) | 8.1 (4.9 – 9.7) | 0.64 |
White Blood Cell count, 103/mm3 | 12.3 (9.3 – 16.8) | 13.8 (10.4 – 22.7) | 0.24 |
Platelet count, 103/mm3 | 104.5 (70.5 – 149.5) | 66.5 (48 – 96.5) | < 0.01 |
Serum creatinine, μM | 62 (53 – 80) | 71 (53 – 88) | 0.35 |
Serum urea, mM | 7.0 (4.3 – 10.3) | 8.6 (6.0 – 13.8) | 0.03 |
Serum glucose, mM | 5.8 (5.0 – 8.1) | 3.3 (1.1 – 6.6) | < 0.01 |
Serum sodium, mM | 131 (128 – 133) | 130 (125 – 135) | 0.48 |
Parasitaemia first day > 4% | 5 (15.1) | 12 (24.0) | 0.41 |
Malnutrition* | 17 (51.5) | 14 (28.0) | 0.03 |
Community-acquired infections | 4 (12.1) | 14 (28.0) | 0.10 |
Quinine loading dose** | 2 (6.1) | 10 (20.0) | 0.11 |
Sedation with clonazepam or thiopental | 22 (66.6) | 12 (24.0) | < 0.001 |
Blood transfusion, n (%) | 18 (54.5) | 21 (42.0) | 0.37 |
Critical care complications*** | 15 (45.5) | 16 (32.0) | 0.21 |