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Table 3 Frequency of dhfr and dhps mutant alleles, genotypic study, Lainé refugee camp

From: Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré

Genotype Frequencies n % 95% CI
dhps (N = 114)    
wild type, 8 7.0 3.1–13.6
single mutant 436 31 27.2 19.3–36.3
single mutant 437 38 33.3 24.8–42.8
double mutant 436–437 29 25.4 17.7–34.4
double mutant 437–540 8 7.0 3.1–13.6
dhfr (N = 148)    
wildtype 20 13.5 8.4–20.1
double mutant 59–108 2 1.4 0.2–4.8
triple mutant 51–59–108 126 85.1 78.4–90.4
dhps and dhfr combined (N = 110)    
quintuple mutant: dhfr 51–59–108 &dhps 437–540 8 7.3 3.2–13.8
quintuple mutant: dhfr 51–59–108 & dhps 436–437 27 24.5 16.8–33.7
dhfr 51–59–108 & dhps single mutant 54 49.1 39.4–58.8
Three or less mutations 21 19.1 12.2–27.7
  1. Dhfr: dihydrofolate reductase
  2. Dhps: dihydropterase synthetase