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Table 2 Classification of treatment outcome

From: Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar

   Treatment group
Treatment outcome   CQ   AQ   SP   AQ+SP   AQ+AS  
14-day follow-up
ETF (%)   4/39 (10.3)   0/38 (0)   0/38 (0)   0/81 (0)*   0/80 (0)*  
LCF (%) OTF (%) 7/39 (17.9) 14/39 (35.9) 0/38 (0)* 0/38 (0) 0/38 (0)* 1/38 (2.6) 0/81 (0)* 1/81 (1.2) 0/80 (0)* 0/80 (0)
LPF (%)   3/39 (7.7)   0/38 (0)   1/38 (2.6)   1/81 (1.2)   0/80 (0)  
ACPR (%)   25/39 (64.1)   38/38 (100)*   37/38 (97.4)*   80/81 (98.8)*   80/80 (100)*  
28-day follow-up non adjusted (PCR-uncorrected)
ETF (%)   4/36 (11.1)   0/36 (0)   0/38 (0)   0/79 (0)*   0/76 (0)*  
LCF (%) OTF (%) 9/36 (25.0) 20/36 (55.5) 3/36 (8.3) 5/36 (13.9) 0/38 (0)* 2/38 (5.2) 2/79 (2.5)* 4/79 (5.0) 3/76 (3.9)* 12/76 (15.7)
LPF (%)   7/36 (19.4)   2/36 (5.6)   2/38 (5.2)   2/79 (2.5)*   9/76 (11.8)  
ACPR (%)   16/36 (44.5)   31/36 (86.1)*   36/38 (94.8)*   75/79 (95.0)*   64/76 (84.3)*  
28-day follow-up adjusted (PCR-corrected)
New infections (%)   4/36 (11.1)   4/36 (11.1)   1/38 (2.6)   1/79 (1.2)**   6/76 (7.9)  
ETF (%)   4/36 (11.1)   0/36 (0)   0/38 (0)   0/79 (0)*   0/76 (0)*  
LCF (%) OTF (%) 7/36 (19.4) 13/36 (44.4) 1/36 (2.8) 1/36 (2.8) 0/38 (0) 1/38 (2.6) 1/79 (1.3)* 3/78 (3.8) 1/76 (1.3)* 6/76 (7.9)
LPF (%)   5/36 (13.9)   0/36 (0)*   1/38 (2.6)   2/79 (2.5)*   5/76 (6.6)  
ACPR (%)   20/36 (55.6)   35/36 (97.2)*   37/38 (97.4)*   76/79 (96.2)*   70/76 (92.1)*  
  1. Data presented are cumulative, failures up to day 14 of follow-up are also considered in the calculation of day 28 failure rates.
  2. Percentages are rounded to achieve totals of 100%.
  3. CQ, Chloroquine; AQ, amodiaquine; SP, Sulphadoxine-pyrimethamine; AS, artesunate ETF, early treatment failure; LCF, late clinical failure; LPF, late parasitological failure; ACPR, adequate clinical and parasitological response.
  4. * Significant difference to CQ group (P < 0.05); ** Significant difference to CQ and AQ groups (P < 0.05).