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Table 2 Clinical and parasitological efficacy of the five antimalarial drug combinations

From: Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal

  Artesunate-amodiaquine N = 360 Artesunate-mefloquine N = 145 Artemether-lumefantrine (four doses) N = 140 Artemether-lumefantrine (six doses) N = 149 Amodiaquine-sulphadoxine-pyrimethamine N = 161
Parasitological failure, day14 0% 0% 0% 0% 0%
Clinical failure, day14 (n) 0% 0% 0.7% (1) 0% 0%
ACPR, day 14 100% 100% 99.3% 0% 100%
Gametocyte carriage, day 14 0% 0% 0% 3% 0%
Parasitological failure, day 21 0% 0% 0% 0% 0%
Clinical failure, day 21 (n) 1.4% (5) 0.7% (1) 3.6% (5) 0% 0.6% (1)
ACPR, day 21 98.6% 99.3% 96.4% 0% 99.4%
Gametocyte carriage, day 21 0% 0% 0% 0% 0%
Parasitological failure, day 28 (n) 0.8% (3) 0% 1.4% (2) 0% 0%
Clinical failure, day 28 (n) 0.3% (1) 1.4% (2) 11.4% (16) 0% 0.6% (1)
ACPR, day 28 97.5% 97.9% 82.8% 0% 98.7%
Gametocyte carriage, day 28 0% 0% 0% 0% 0%
ACPR, day 28 after PCR 100% 100% 96.4% 100% 100%
ACPR, day 42 (30% of patients) 100% 100% 100% 100% 100%