Table 6 Biological tolerance to the five antimalarial drug combinations on days 14 and 28.
Day | Artesunate-amodiaquine | Artesunate-mefloquine | Artemether-lumefantrine (four doses) | Artemether-lumefantrine (six doses) | Amodiaquine-sulphadoxine-pyrimethamine | |
|---|---|---|---|---|---|---|
Anemia (Hb < 12) | 0 | 35/51 | 15/24 | 30/31 | 24/35 | 19/27 |
68.6% | 62.5% | 96.7% | 68.6% | 70.3% | ||
14 | 40/51 | 17/24 | 20/31 | 24/35 | 21/27 | |
80.4% | 70.8% | 64.5% | 68.6% | 77.7% | ||
SGOT > 30 | 0 | 9/59 | 0/27 | 3/31 | 6/35 | 0/27 |
15.2% | 0% | 9.7% | 17.1% | 0% | ||
14 | 16/59 | 8/27 | 8/31 | 04/35 | 10/31 | |
27.1% | 29.6% | 25.9% | 11.4% | 32.2% | ||
SGPT > 35 | 0 | 0/59 | 0/27 | 0/31 | 1/35 | 0/27 |
0% | 0% | 0% | 2.8% | 0% | ||
14 | 3/58 | 3/27 | 4/31 | 1/35 | 2/31 | |
5.1% | 11.1% | 13% | 2.8% | 6.4% | ||
Creatininemia > 14 | 0 | 0/59 | 0/27 | 0/37 | 30% | 0/27 |
0% | 0% | 0% | 0% | |||
14 | 3/58 | 2/27 | 1/37 | 9/35 | 2/31 | |
5.1% | 7.4% | 2.8% | 25.7% | 6.4% |