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Table 6 Biological tolerance to the five antimalarial drug combinations on days 14 and 28.

From: Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal

  Day Artesunate-amodiaquine Artesunate-mefloquine Artemether-lumefantrine (four doses) Artemether-lumefantrine (six doses) Amodiaquine-sulphadoxine-pyrimethamine
Anemia (Hb < 12) 0 35/51 15/24 30/31 24/35 19/27
   68.6% 62.5% 96.7% 68.6% 70.3%
  14 40/51 17/24 20/31 24/35 21/27
   80.4% 70.8% 64.5% 68.6% 77.7%
SGOT > 30 0 9/59 0/27 3/31 6/35 0/27
   15.2% 0% 9.7% 17.1% 0%
  14 16/59 8/27 8/31 04/35 10/31
   27.1% 29.6% 25.9% 11.4% 32.2%
SGPT > 35 0 0/59 0/27 0/31 1/35 0/27
   0% 0% 0% 2.8% 0%
  14 3/58 3/27 4/31 1/35 2/31
   5.1% 11.1% 13% 2.8% 6.4%
Creatininemia > 14 0 0/59 0/27 0/37 30% 0/27
   0% 0% 0%   0%
  14 3/58 2/27 1/37 9/35 2/31
   5.1% 7.4% 2.8% 25.7% 6.4%