Table 3 The in vitro IC50 responses of a subset of Plasmodium falciparum isolates (n = 22) to Ferroquine, Ferroquine metabolite, Doxycyxline, Lumefantrine, Mefloquine, and Piperaquine. Ferroquine cross-resistance with the other antimalarials was estimated by Pearson correlation coefficient (r), and coefficient of determination (r2).
Mean inhibitory concentration (nM) | ||||||
|---|---|---|---|---|---|---|
Drug | No. of isolates | Geometric mean | 95% confidence interval | r | r 2 | P |
Ferroquine | 21 | 8.91 | 8.17 – 9.72 | - | - | - |
FQ-Metabolite | 22 | 31.40 | 28.16 – 35.01 | 0.674 | 0.4542 | 0.001 |
Doxycycline | 20 | 2719.85 | 2236.38 – 3307.09 | -0.203 | 0.0411 | 0.391 |
Lumefantrine | 22 | 11.77 | 10.31 – 13.44 | 0.486 | 0.2364 | 0.025 |
Mefloquine | 21 | 144.23 | 125.82 – 165.33 | 0.296 | 0.0874 | 0.206 |
Piperaquine | 19 | 49.20 | 37.16 – 65.11 | 0.017 | 0.0003 | 0.946 |